Document Detail


Current advances in the translation of vascular tissue engineering to the treatment of pediatric congenital heart disease.
MedLine Citation:
PMID:  22737051     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Tissue-engineered vascular grafts (TEVGs) hold great promise for the improvement of outcomes in pediatric patients with congenital cardiac anomalies. Currently used synthetic grafts have several limitations, including thrombogenicity, increased risk of infection, and lack of growth potential. The first pilot clinical trial of TEVGs demonstrated the feasibility of this new technology and revealed an excellent safety profile. However, long-term follow-up from this trial revealed the primary graft-related complication to be stenosis, affecting 16 percent of grafts within 7 years post-implantation. In order to determine the mechanism behind TEVG stenosis and ultimately to create improved second generation TEVGs, our group has returned to the bench to study vascular neotissue formation in a variety of large and small animal models. The purpose of this report is to review the recent advances in the understanding of neotissue formation and vascular tissue engineering.
Authors:
Ethan W Dean; Brooks Udelsman; Christopher K Breuer
Publication Detail:
Type:  Journal Article; Review     Date:  2012-06-25
Journal Detail:
Title:  The Yale journal of biology and medicine     Volume:  85     ISSN:  1551-4056     ISO Abbreviation:  Yale J Biol Med     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-06-27     Completed Date:  2012-10-30     Revised Date:  2013-07-12    
Medline Journal Info:
Nlm Unique ID:  0417414     Medline TA:  Yale J Biol Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  229-38     Citation Subset:  IM    
Affiliation:
Interdepartmental Program in Vascular Biology and Therapeutics, Yale School of Medicine, New Haven, CT 06520, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Vessel Prosthesis*
Blood Vessel Prosthesis Implantation / methods,  trends
Child
Heart Defects, Congenital / surgery*
Humans
Models, Animal
Tissue Engineering / methods*,  trends
Tissue Scaffolds
Translational Medical Research / methods*,  trends
Comments/Corrections

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