| Current views on the roles of Th1 and Th17 cells in experimental autoimmune encephalomyelitis. | |
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MedLine Citation:
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PMID: 20107924 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE), are autoimmune demyelinating diseases of the central nervous system (CNS). Interferon-gamma-producing Th1 and interleukin-17-producing Th17 CD4(+) T helper (Th) cells mediate disease pathogenesis in EAE and likely in MS as well. However, the relative contribution of each Th subset to autoimmune processes in the CNS remains unclear. Emerging data suggest that both Th1 and Th17 cells contribute to CNS autoimmunity, albeit through different mechanisms. A better understanding of the roles that Th1 and Th17 cells play in autoimmune inflammation will be helpful in developing new therapeutic approaches. In this review, we discuss recent findings on the roles of Th1 and Th17 cells in the pathogenesis of EAE. |
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Authors:
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Mohamed El-behi; Abdolmohamad Rostami; Bogoljub Ciric |
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Publication Detail:
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Type: Journal Article; Review Date: 2010-01-27 |
Journal Detail:
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Title: Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology Volume: 5 ISSN: 1557-1904 ISO Abbreviation: J Neuroimmune Pharmacol Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-10 Completed Date: 2010-08-03 Revised Date: 2011-07-28 |
Medline Journal Info:
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Nlm Unique ID: 101256586 Medline TA: J Neuroimmune Pharmacol Country: United States |
Other Details:
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Languages: eng Pagination: 189-97 Citation Subset: IM |
Affiliation:
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Department of Neurology, Thomas Jefferson University, Ste. 300 JHN, 900 Walnut Street, Philadelphia, PA 19107, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals CD4-Positive T-Lymphocytes / metabolism, physiology* Encephalomyelitis, Autoimmune, Experimental / immunology* Humans Interleukin-17 / biosynthesis, physiology* Interleukin-23 / physiology Receptors, Chemokine / physiology Th1 Cells / metabolism, physiology* |
| Grant Support | |
ID/Acronym/Agency:
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R01 NS046782-05A2/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-17; 0/Interleukin-23; 0/Receptors, Chemokine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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