| Current knowledge of Trichosporon spp. and Trichosporonosis. | |
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MedLine Citation:
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PMID: 21976604 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Trichosporon spp. are basidiomycetous yeast-like fungi found widely in nature. Clinical isolates are generally related to superficial infections. However, this fungus has been recognized as an opportunistic agent of invasive infections, mostly in cancer patients and those exposed to invasive medical procedures. It is possible that the ability of Trichosporon strains to form biofilms on implanted devices, the presence of glucuronoxylomannan in their cell walls, and the ability to produce proteases and lipases are all factors likely related to the virulence of this genus and therefore may account for the progress of invasive trichosporonosis. Disseminated trichosporonosis has been increasingly reported worldwide and represents a challenge for both diagnosis and species identification. Phenotypic identification methods are useful for Trichosporon sp. screening, but only molecular methods, such as IGS region sequencing, allow the complete identification of Trichosporon isolates at the species level. Methods for the diagnosis of invasive trichosporonosis include PCR-based methods, Luminex xMAP technology, and, more recently, proteomics. Treating patients with trichosporonosis remains a challenge because of limited data on the in vitro and in vivo activities of antifungal drugs against clinically relevant species of the genus. Despite the mentioned limitations, the use of antifungal regimens containing triazoles appears to be the best therapeutic approach. |
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Authors:
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Arnaldo L Colombo; Ana Carolina B Padovan; Guilherme M Chaves |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Clinical microbiology reviews Volume: 24 ISSN: 1098-6618 ISO Abbreviation: Clin. Microbiol. Rev. Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-06 Completed Date: 2012-04-02 Revised Date: 2013-02-08 |
Medline Journal Info:
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Nlm Unique ID: 8807282 Medline TA: Clin Microbiol Rev Country: United States |
Other Details:
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Languages: eng Pagination: 682-700 Citation Subset: IM |
Affiliation:
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Laboratório Especial de Micologia, Disciplina de Infectologia, Universidade Federal de São Paulo, Brazil. colomboal@terra.com.br |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antifungal Agents / therapeutic use Humans Triazoles / therapeutic use Trichosporon / physiology* Trichosporonosis / drug therapy, microbiology* |
| Chemical | |
Reg. No./Substance:
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0/Antifungal Agents; 0/Triazoles |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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