| Current Concepts on the Pathogenesis and Natural History of Steroid-Induced Osteonecrosis. | |
| | |
MedLine Citation:
|
PMID: 21161435 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
The pathophysiology of non-traumatic osteonecrosis is more complex than that of traumatic osteonecrosis, and corticosteroid-induced osteonecrosis presents the greatest challenge because of the multiple effects of corticosteroids on multi-system pathways; these pathways include the effects of corticosteroids on osteoblast differentiation, osteoblast and osteoclast apoptosis, lipid metabolism, coagulation pathways, and calcium metabolism. These pathways are frequently interrelated with each other, which makes the pathogenesis even more difficult to understand. Host factors and underlying disease have been shown to play a significant role in the risk of developing osteonecrosis, and our understanding of the pathogenesis must be able to explain why some patients are at greater risk than others. Identification of genetic variants that convey additional risk will also help to personalize the way we deliver care, both in the prevention and treatment of osteonecrosis. Further understanding of the intricate immunologic and genetic pathways contributing to osteonecrosis is at the forefront of research and may soon lead to viable and less invasive non-surgical therapeutic strategies. |
| | |
Authors:
|
Christian Powell; Christopher Chang; M Eric Gershwin |
Related Documents
:
|
8604025 - Progesterone inhibits inducible nitric oxide synthase gene expression and nitric oxide ... 7532825 - Expression of inducible nitric oxide synthase causes delayed neurotoxicity in primary m... 10859695 - Acid-dependent dismutation of nitrogen oxides may be a critical source of nitric oxide ... 12810105 - L-arginine metabolism in myeloid cells controls t-lymphocyte functions. 12857775 - Reprogramming the host response in bacterial meningitis: how best to improve outcome? 16321465 - Expression of apoptotic nuclei by ultrastructural terminal deoxyribonucleotidyl transfe... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2010-12-16 |
Journal Detail:
|
Title: Clinical reviews in allergy & immunology Volume: - ISSN: 1559-0267 ISO Abbreviation: - Publication Date: 2010 Dec |
Date Detail:
|
Created Date: 2010-12-16 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9504368 Medline TA: Clin Rev Allergy Immunol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis School of Medicine, 451 Health Sciences Drive, Suite 6510, Davis, CA, 95616, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Minimally invasive procedures for evacuation of intracerebral hemorrhage reduces perihematomal gluta...
Next Document: The selection of acute medical admissions for a short-stay unit.