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Curious Cases: Acromegaly and Schizophrenia: An Incidental Association?
MedLine Citation:
PMID:  24603061     Owner:  NLM     Status:  Publisher    
Objective: Acromegaly associated to schizophrenia was first reported ~60 years ago, and so far, it is unclear whether this association is causal or not. Our aim was to report new cases with both clinical entities and to discuss the potential pathophysiological mechanisms of this association. Methods: Three new cases and data from literature are reviewed. Results: We report 2 males and 1 female diagnosed with schizophrenia and treated for several years with antipsychotics who developed acromegaly due to a growth hormone (GH)-secreting pituitary macroadenoma. In all cases, the diagnosis of schizophrenia preceded acromegaly with mean disease duration of ~12 years. Antipsychotic therapy was different in every patient. Two patients underwent transsphenoidal surgery. Histopathological study showed mixed GH- and prolactin-secreting adenoma in 1 patient and pure GH-secreting adenoma in the other patient. Several pathophysiological mechanisms related to alterations in dopaminergic neurotransmission due to psychiatric disease itself or its pharmacological treatment are proposed and discussed as likely linkage between schizophrenia and acromegaly. Conclusion: These case reports suggest that schizophrenia and/or its antipsychotic therapy in the long term might be in relation with the development of GH-secreting pituitary adenomas.
Pedro Iglesias; Carmen Bernal; Juan J Díez
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-3-6
Journal Detail:
Title:  Schizophrenia bulletin     Volume:  -     ISSN:  1745-1701     ISO Abbreviation:  Schizophr Bull     Publication Date:  2014 Mar 
Date Detail:
Created Date:  2014-3-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0236760     Medline TA:  Schizophr Bull     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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