Document Detail


Curing epilepsy: progress and future directions.
MedLine Citation:
PMID:  19341977     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
During the past decade, substantial progress has been made in delineating clinical features of the epilepsies and the basic mechanisms responsible for these disorders. Eleven human epilepsy genes have been identified and many more are now known from animal models. Candidate targets for cures are now based upon newly identified cellular and molecular mechanisms that underlie epileptogenesis. However, epilepsy is increasingly recognized as a group of heterogeneous syndromes characterized by other conditions that co-exist with seizures. Cognitive, emotional and behavioral co-morbidities are common and offer fruitful areas for study. These advances in understanding mechanisms are being matched by the rapid development of new diagnostic methods and therapeutic approaches. This article reviews these areas of progress and suggests specific goals that once accomplished promise to lead to cures for epilepsy.
Authors:
Margaret P Jacobs; Gabrielle G Leblanc; Amy Brooks-Kayal; Frances E Jensen; Dan H Lowenstein; Jeffrey L Noebels; Dennis D Spencer; John W Swann
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Epilepsy & behavior : E&B     Volume:  14     ISSN:  1525-5069     ISO Abbreviation:  Epilepsy Behav     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-04-03     Completed Date:  2009-06-16     Revised Date:  2014-09-20    
Medline Journal Info:
Nlm Unique ID:  100892858     Medline TA:  Epilepsy Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  438-45     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Anticonvulsants / therapeutic use
Comorbidity
Epilepsy / complications,  diagnosis*,  epidemiology,  etiology,  genetics,  therapy*
Humans
Neurosurgical Procedures
Grant Support
ID/Acronym/Agency:
R01 NS031718/NS/NINDS NIH HHS; R01 NS031718-08/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Anticonvulsants
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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