Document Detail


Curing HIV: lessons from cancer therapy.
MedLine Citation:
PMID:  23454863     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE OF REVIEW: Interest in finding a potential 'cure' for HIV has taken on greater interest and urgency since the report of an individual who underwent allogeneic stem cell transplant from a CCR5 delta 32 homozygote donor after high-dose chemotherapy for acute myeloid leukemia. The potential role of cancer chemotherapy and other cancer-directed treatment approaches is discussed in the context of their potential role in helping to eliminate HIV from the infected host.
RECENT FINDINGS: Cancer chemotherapy and other cancer-targeted agents have been used successfully in treating a variety of malignancies in both HIV-infected and HIV-uninfected individuals. Lessons learned from these strategies may be of importance in helping to define more effective ways of controlling and eliminating HIV as well. Application of these anticancer strategies to patients with HIV are beginning to be explored and may help determine their potential usefulness in this disease as well.
SUMMARY: Although cytotoxic chemotherapy is a crude and not particularly effective way of removing HIV latently infected cells and tissue reservoirs, several new approaches to targeting and controlling cancer proliferation may be of value in HIV cure research and may one day help to end this disease.
Authors:
Ronald Mitsuyasu
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review    
Journal Detail:
Title:  Current opinion in HIV and AIDS     Volume:  8     ISSN:  1746-6318     ISO Abbreviation:  Curr Opin HIV AIDS     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-04-11     Completed Date:  2013-09-25     Revised Date:  2013-10-17    
Medline Journal Info:
Nlm Unique ID:  101264945     Medline TA:  Curr Opin HIV AIDS     Country:  United States    
Other Details:
Languages:  eng     Pagination:  224-9     Citation Subset:  IM; X    
Affiliation:
David Geffen School of Medicine at UCLA, UCLA Center for Clinical AIDS Research and Education (CARE Center), University of California, Los Angeles, CA 90035, USA. rmitsuya@mednet.ucla.edu
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MeSH Terms
Descriptor/Qualifier:
HIV Infections / surgery,  therapy*
Hematopoietic Stem Cell Transplantation
Humans
Neoplasms / surgery,  therapy*
Grant Support
ID/Acronym/Agency:
AI 069424/AI/NIAID NIH HHS; AI 28697/AI/NIAID NIH HHS; CA 121947/CA/NCI NIH HHS; MH 087222/MH/NIMH NIH HHS; P30 AI028697/AI/NIAID NIH HHS; R25 MH087222/MH/NIMH NIH HHS; U01 AI069424/AI/NIAID NIH HHS; U01 CA121947/CA/NCI NIH HHS; UL1 TR000124/TR/NCATS NIH HHS; UL1TR000124/TR/NCATS NIH HHS
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