| Curcumin or saikosaponin a improves hepatic antioxidant capacity and protects against CCl4-induced liver injury in rats. | |
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MedLine Citation:
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PMID: 18598162 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Curcumin and saikosaponin a, the bioactive phytochemicals of turmeric and Bupleurum, act as antioxidants. This study investigated the effects of supplementation with curcumin and/or saikosaponin a on hepatic lipids and antioxidant status in rats with CCl(4)-induced liver injury. Male Sprague-Dawley rats were randomly divided into control, CCl(4), CCl(4) + curcumin (0.005%; CU), CCl(4) + saikosaponin a (0.004%; SS), and CCl(4) + curcumin + saikosaponin a (0.005% + 0.004%; CU+SS) groups. CCl(4) (40% in olive oil) was injected intraperitoneally at a dose of 0.75 mL/kg once a week. Curcumin and/or saikosaponin a was administered orally 1 week before CCl(4) injection for 8 weeks. The pathological results showed that liver fibrosis was ameliorated in the SS and CU+SS groups. After 8 weeks, supplementation with curcumin and/or saikosaponin a significantly decreased plasma alanine aminotransferase and aspartate aminotransferase activities, as well as plasma and hepatic cholesterol and triglyceride levels. The CU+SS group showed reversal of the impaired hepatic superoxide dismutase activity and an increase in total glutathione level. Supplementation with curcumin and/or saikosaponin a significantly improved hepatic antioxidant status and suppressed malondialdehyde formation. Therefore, supplementation with curcumin and/or saikosaponin a protects against CCl(4)-induced liver injury by attenuating hepatic lipids and lipid peroxidation and enhancing antioxidant defense. Curcumin and saikosaponin a had no additive effects on hepatoprotection except for greater improvement in the total glutathione level and antioxidant status. |
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Authors:
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Shu-Ju Wu; Yun-Ho Lin; Chia-Chou Chu; Ya-Hui Tsai; Jane C-J Chao |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of medicinal food Volume: 11 ISSN: 1557-7600 ISO Abbreviation: J Med Food Publication Date: 2008 Jun |
Date Detail:
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Created Date: 2008-07-07 Completed Date: 2008-11-10 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 9812512 Medline TA: J Med Food Country: United States |
Other Details:
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Languages: eng Pagination: 224-9 Citation Subset: IM |
Affiliation:
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Schools of Pharmacy, Taipei Medical University, Taipei, Republic of China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alanine Transaminase
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blood Animals Antioxidants / analysis* Aspartate Aminotransferases / blood Carbon Tetrachloride / toxicity* Curcumin / administration & dosage* Drug-Induced Liver Injury Glutathione / analysis Lipids / analysis, blood Liver / chemistry*, drug effects, enzymology Liver Diseases / drug therapy*, physiopathology Male Oleanolic Acid / administration & dosage, analogs & derivatives* Rats Rats, Sprague-Dawley Saponins / administration & dosage* Superoxide Dismutase / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Lipids; 0/Saponins; 20874-52-6/saikosaponin; 458-37-7/Curcumin; 508-02-1/Oleanolic Acid; 56-23-5/Carbon Tetrachloride; 70-18-8/Glutathione; EC 1.15.1.1/Superoxide Dismutase; EC 2.6.1.1/Aspartate Aminotransferases; EC 2.6.1.2/Alanine Transaminase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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