Document Detail


Curcumin reduces indomethacin-induced damage in the rat small intestine.
MedLine Citation:
PMID:  17351913     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used in clinical medicine. Their utility is, however, often limited by the adverse effects they produce in the gastrointestinal tract. Oxidative stress has been shown to occur in the small intestine in response to the oral administration of indomethacin, an NSAID commonly used in toxicity studies. In view of this, the effect of curcumin, an agent with anti-oxidant properties, was evaluated on indomethacin-induced small intestinal damage in a rat model. Rats were pretreated with various doses of curcumin (20 mg kg(-1), 40 mg kg(-1) and 80 mg kg(-1)) before administering indomethacin at 20 mg kg(-1). Various parameters of oxidative stress and the extent of small intestinal damage produced by indomethacin, with and without pretreatment with curcumin, were measured. Macroscopic ulceration was found to occur in the small intestine in response to indomethacin. The viability of enterocytes from indomethacin-treated animals was significantly lower than those from control animals. Drug-induced oxidative stress was also evident as seen by increases in the levels of malondialdehyde and protein carbonyl and in activities of pro-oxidant enzymes such as myeloperoxidase and xanthine oxidase in indomethacin-treated rats. Concomitant decreases were seen in the activities of the antioxidant enzymes catalase and glutathione peroxidase in these animals. Pretreatment with curcumin was found to ameliorate these drug-induced changes. Thus, curcumin appears to hold promise as an agent that can potentially reduce NSAID-induced small intestinal damage.
Authors:
Nageswaran Sivalingam; Raghunath Hanumantharaya; Minnie Faith; Jayasree Basivireddy; K A Balasubramanian; Molly Jacob
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of applied toxicology : JAT     Volume:  27     ISSN:  0260-437X     ISO Abbreviation:  J Appl Toxicol     Publication Date:    2007 Nov-Dec
Date Detail:
Created Date:  2007-10-30     Completed Date:  2007-12-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8109495     Medline TA:  J Appl Toxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  551-60     Citation Subset:  IM    
Affiliation:
Department of Biochemistry, Christian Medical College, Vellore-632002, Tamil Nadu, India.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antioxidants / pharmacology*,  therapeutic use
Caspases / metabolism
Catalase / metabolism
Cell Survival / drug effects
Curcumin / pharmacology*,  therapeutic use
Disease Models, Animal
Dose-Response Relationship, Drug
Duodenal Ulcer / chemically induced,  metabolism,  pathology,  prevention & control*
Enterocytes / drug effects,  metabolism,  pathology
Glutathione Peroxidase
Indomethacin
Intestine, Small / drug effects*,  enzymology,  metabolism,  pathology
Male
Malondialdehyde / metabolism
Oxidative Stress / drug effects*
Peroxidase / metabolism
Protein Carbonylation / drug effects
Rats
Rats, Wistar
Xanthine Oxidase / metabolism
Chemical
Reg. No./Substance:
0/Antioxidants; 458-37-7/Curcumin; 53-86-1/Indomethacin; 542-78-9/Malondialdehyde; EC 1.11.1.6/Catalase; EC 1.11.1.7/Peroxidase; EC 1.11.1.9/Glutathione Peroxidase; EC 1.17.3.2/Xanthine Oxidase; EC 3.4.22.-/Caspases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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