| Curcumin promotes apoptosis in human lung adenocarcinoma cells through miR-186* signaling pathway. | |
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MedLine Citation:
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PMID: 20878113 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Lung cancer is one of the leading causes of cancer-related death worldwide. Curcumin has been reported to have an antitumor effect by inducing apoptosis and suppressing growth of tumor cells. However, the mechanism by which curcumin exerts its anti-cancer effect needs further research. The purpose of the present study was to identify a miRNA-mediated mechanism which plays a role in the anti-cancer effects of curcumin. Alterations in miRNA expression were seen in curcumin-treated A549 cells, including significant downregulation of miRNA-186* expression by microarray analysis and real-time PCR. The miRNA-186* functions by overexpression or inhibition were investigated using biological assays in A549 cells. Additionally, caspase-10 was identified as a target of miRNA-186* using dual luciferase reporter assays and western blot analysis. These results demonstrate that curcumin induces A549 cell apoptosis through a miRNA pathway. Also, miRNA-186* could serve as a potential gene therapy target in curcumin treatment. furthermore, caspase-10 was shown to be a target of miR-186* regulation. |
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Authors:
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Jian Zhang; Yongping Du; Changgui Wu; Xinling Ren; Xinyu Ti; Jieran Shi; Feng Zhao; Hong Yin |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Oncology reports Volume: 24 ISSN: 1791-2431 ISO Abbreviation: Oncol. Rep. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-09-29 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9422756 Medline TA: Oncol Rep Country: Greece |
Other Details:
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Languages: eng Pagination: 1217-23 Citation Subset: IM |
Affiliation:
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Department of Respiratory Medicine, Xijing Hospital, The Fourth Military Medical University, Xi'an 710032, PR China. zhangjian197011@yahoo.com |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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