Document Detail


Curcumin and neurodegenerative diseases.
MedLine Citation:
PMID:  23303664     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Over the last 10 years curcumin has been reported to be effective against a wide variety of diseases and is characterized as having anticarcinogenic, hepatoprotective, thrombosuppressive, cardioprotective, antiarthritic, and anti-infectious properties. Recent studies performed in both vertebrate and invertebrate models have been conducted to determine whether curcumin was also neuroprotective. The efficacy of curcumin in several preclinical trials for neurodegenerative diseases has created considerable excitement mainly because of its lack of toxicity and low cost. This suggests that curcumin could be a worthy candidate for nutraceutical intervention. As aging is a common risk factor for neurodegenerative diseases, it is possible that some compounds that target aging mechanisms could also prevent these kinds of diseases. One potential mechanism to explain several of the general health benefits associated with curcumin is that it may prevent aging-associated changes in cellular proteins that lead to protein insolubility and aggregation. This loss in protein homeostasis is associated with several age-related diseases. Recently, curcumin has been found to help maintain protein homeostasis and extend lifespan in the model invertebrate Caenorhabditis elegans. Here, we review the evidence from several animal models that curcumin improves healthspan by preventing or delaying the onset of various neurodegenerative diseases.
Authors:
Adriana Monroy; Gordon J Lithgow; Silvestre Alavez
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2013-01-10
Journal Detail:
Title:  BioFactors (Oxford, England)     Volume:  39     ISSN:  1872-8081     ISO Abbreviation:  Biofactors     Publication Date:    2013 Jan-Feb
Date Detail:
Created Date:  2013-02-20     Completed Date:  2013-08-05     Revised Date:  2014-01-23    
Medline Journal Info:
Nlm Unique ID:  8807441     Medline TA:  Biofactors     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  122-32     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 International Union of Biochemistry and Molecular Biology, Inc.
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MeSH Terms
Descriptor/Qualifier:
Aging
Animals
Cells, Cultured
Clinical Trials as Topic
Curcumin / pharmacology,  therapeutic use*
Disease Models, Animal
Drug Evaluation, Preclinical
Humans
Neurodegenerative Diseases / drug therapy*,  metabolism,  prevention & control
Neuroprotective Agents / pharmacology,  therapeutic use*
Grant Support
ID/Acronym/Agency:
AG029631-01A1/AG/NIA NIH HHS; AG21069/AG/NIA NIH HHS; AG22868/AG/NIA NIH HHS; ES016655/ES/NIEHS NIH HHS; R01 AG029631/AG/NIA NIH HHS; U19AGO231222//PHS HHS; UL1RR024917/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Neuroprotective Agents; IT942ZTH98/Curcumin
Comments/Corrections

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