| Curcumin inhibits the growth of AGS human gastric carcinoma cells in vitro and shows synergism with 5-fluorouracil. | |
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MedLine Citation:
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PMID: 15298755 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The inhibitory effect of curcumin and its synergism with 5-fluorouracil (5-FU) on the growth of the AGS human gastric carcinoma cell line was examined. Cell cycle analysis was used to elucidate the mechanisms for the inhibition by curcumin. Curcumin significantly inhibited the growth of AGS cells in a dose- and time-dependent manner (P <.05). Curcumin caused a 34% decrease in AGS proliferation at 5 micromol/L, 51% at 10 micromol/L, and 92% at 25 micromol/L after 4 days of treatment. When curcumin (10 micromol/L) was removed after a 24-hour exposure, the growth pattern of curcumin-treated AGS cells was similar to that of control cells, suggesting reversibility of curcumin on the growth of AGS cells. Combining curcumin with 5-FU significantly increased growth inhibition of AGS cells compared with either curcumin or 5-FU alone (P <.05), suggesting synergistic actions of the two drugs. After 4 days of treatment with 10 micromol/L of curcumin, the G2/M phase fraction of cells was 60.5% compared with 22.0% of the control group, suggesting a G2/M block by curcumin treatment. Because the curcumin concentrations (5 micromol/L) used in our study were similar to steady-state concentrations (1.77 +/- 1.87 micromol/L) in human serum of subjects receiving chronic administration of a commonly recommended dose (8 g/day), curcumin may be useful for the treatment of gastric carcinoma, especially in conjunction with 5-FU. |
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Authors:
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Ja Young Koo; Hyun Joo Kim; Keun-Ok Jung; Kun-Young Park |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of medicinal food Volume: 7 ISSN: 1096-620X ISO Abbreviation: J Med Food Publication Date: 2004 |
Date Detail:
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Created Date: 2004-08-09 Completed Date: 2004-10-07 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9812512 Medline TA: J Med Food Country: United States |
Other Details:
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Languages: eng Pagination: 117-21 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine and Cancer Research Institute, College of Medicine, Kosin University, 34 Annam-dong, Seoku, Busan 602-703, Korea. jykoo@ns.kosinmed.or.kr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cell Division
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drug effects* Curcumin / administration & dosage, pharmacology* Dose-Response Relationship, Drug Drug Synergism Fluorouracil / pharmacology* G2 Phase / drug effects Humans Mitosis / drug effects Stomach Neoplasms / pathology* Tumor Cells, Cultured |
| Chemical | |
Reg. No./Substance:
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458-37-7/Curcumin; 51-21-8/Fluorouracil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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