| Curcumin inhibition of Dermatophagoides farinea-induced interleukin-5 (IL-5) and granulocyte macrophage-colony stimulating factor (GM-CSF) production by lymphocytes from bronchial asthmatics. | |
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MedLine Citation:
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PMID: 9353136 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Curcumin, a dietary pigment responsible for the yellow color of curry, has been used for the treatment of inflammatory diseases and exhibits a variety of pharmacological effects such as anti-inflammatory, anti-tumor, anti-oxidant, and anti-viral activity. However, it has not been determined whether the effect of curcumin on the production of cytokine affects eosinophil functions and IgE synthesis. In the present study, we examined the effect of curcumin on the production of interleukin (IL)-2, IL-5, granulocyte macrophage-colony stimulating factor (GM-CSF), and IL-4 by lymphocytes from atopic asthmatics in response to house dust mites (Dermatophagoides farinea: Df) in order to clarify a potential application for allergic diseases. Curcumin inhibited Df-induced lymphocyte proliferation and production of IL-2. Exogenous IL-2 reconstituted the proliferative responsiveness of lymphocytes to Df in the presence of curcumin. Furthermore, curcumin inhibited IL-5, GM-CSF, and IL-4 production in a concentration-dependent manner. These results indicate that curcumin may have a potential effect on controlling allergic diseases through inhibiting the production of cytokines affecting eosinophil function and IgE synthesis. |
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Authors:
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T Kobayashi; S Hashimoto; T Horie |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biochemical pharmacology Volume: 54 ISSN: 0006-2952 ISO Abbreviation: Biochem. Pharmacol. Publication Date: 1997 Oct |
Date Detail:
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Created Date: 1997-11-13 Completed Date: 1997-11-13 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0101032 Medline TA: Biochem Pharmacol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 819-24 Citation Subset: IM |
Affiliation:
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First Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Animals Anti-Inflammatory Agents, Non-Steroidal / pharmacology* Asthma / drug therapy, immunology* Curcumin / pharmacology* Dose-Response Relationship, Drug Granulocyte-Macrophage Colony-Stimulating Factor / biosynthesis* Humans Interleukin-4 / biosynthesis Interleukin-5 / biosynthesis* Lymphocyte Activation / drug effects Lymphocytes / metabolism* Mites / immunology* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents, Non-Steroidal; 0/Interleukin-5; 207137-56-2/Interleukin-4; 458-37-7/Curcumin; 83869-56-1/Granulocyte-Macrophage Colony-Stimulating Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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