Document Detail


Curcumin attenuates cerebral edema following traumatic brain injury in mice: a possible role for aquaporin-4?
MedLine Citation:
PMID:  20132469     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Traumatic brain injury is a devastating neurological injury associated with significant morbidity and mortality. Medical therapies to limit cerebral edema, a cause of increased intracranial hypertension and poor clinical outcome, are largely ineffective, emphasizing the need for novel therapeutic approaches. In the present study, pre-treatment with curcumin (75, 150 mg/kg) or 30 min post-treatment with 300 mg/kg significantly reduced brain water content and improved neurological outcome following a moderate controlled cortical impact in mice. The protective effect of curcumin was associated with a significant attenuation in the acute pericontusional expression of interleukin-1beta, a pro-inflammatory cytokine, after injury. Curcumin also reversed the induction of aquaporin-4, an astrocytic water channel implicated in the development of cellular edema following head trauma. Notably, curcumin blocked IL-1beta-induced aquaporin-4 expression in cultured astrocytes, an effect mediated, at least in part, by reduced activation of the p50 and p65 subunits of nuclear factor kappaB. Consistent with this notion, curcumin preferentially attenuated phosphorylated p65 immunoreactivity in pericontusional astrocytes and decreased the expression of glial fibrillary acidic protein, a reactive astrocyte marker. As a whole, these data suggest clinically achievable concentrations of curcumin reduce glial activation and cerebral edema following neurotrauma, a finding which warrants further investigation.
Authors:
Melissa D Laird; Sangeetha Sukumari-Ramesh; Andrew E B Swift; Steffen E Meiler; John R Vender; Krishnan M Dhandapani
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-01-20
Journal Detail:
Title:  Journal of neurochemistry     Volume:  113     ISSN:  1471-4159     ISO Abbreviation:  J. Neurochem.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-16     Completed Date:  2010-05-04     Revised Date:  2013-05-31    
Medline Journal Info:
Nlm Unique ID:  2985190R     Medline TA:  J Neurochem     Country:  England    
Other Details:
Languages:  eng     Pagination:  637-48     Citation Subset:  IM    
Affiliation:
Department of Neurosurgery, Medical College of Georgia, Augusta, Georgia, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
Aquaporin 4 / antagonists & inhibitors*
Blotting, Western
Brain Edema / etiology*,  pathology,  prevention & control*
Brain Injuries / complications*,  pathology,  psychology
Cells, Cultured
Curcumin / pharmacology*
Immunohistochemistry
Interleukin-1beta / antagonists & inhibitors,  biosynthesis,  physiology
Learning / physiology
Male
Memory / physiology
Mice
Microscopy, Confocal
NF-kappa B / antagonists & inhibitors,  metabolism
Recognition (Psychology) / physiology
Reverse Transcriptase Polymerase Chain Reaction
Signal Transduction / drug effects
Grant Support
ID/Acronym/Agency:
NS065172/NS/NINDS NIH HHS; R01 NS065172/NS/NINDS NIH HHS; R01 NS065172-01A2/NS/NINDS NIH HHS; R01 NS065172-03/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Aquaporin 4; 0/Interleukin-1beta; 0/NF-kappa B; 458-37-7/Curcumin
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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