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Curcumin alleviates immune-complex mediated glomerulonephritis in factor H deficient mice.
MedLine Citation:
PMID:  23347386     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Complement factor H (Cfh) is a key regulator of the complement cascade and protects the C57BL6 mice from immune complex (IC)-mediated complement-dependent glomerulonephritis (GN). In chronic serum sickness there are increased deposits of immune complexes in the glomeruli with inflammation and a scarring phenotype. Since cucurmin, is an effective anti-inflammatory agent and reduces complement activation, we hypothesized that it should alleviate renal disease in this setting. To determine the effectiveness of curcumin, apoferritin induced serum sickness (CSS) model in Cfh-deficient (Cfh-/-) mice was used. Curcumin (CMN) treatment (30mg/kg) given every day in parallel with apoferritin reduced glomerulonephritis and enhanced kidney function (BUN, 45.4 + 7.5 vs 35.6 + 5.1; albuminuria, 50.1 + 7.1 vs 15.7 + 7.1; GN, 2.62 + 0.25 vs 2 + 0.3, p<0.05). In line with reduced IgG deposits in mice with CSS given CMN, C9 deposits were reduced indicating reduced complement activation. Mice treated with CMN had a significant reduction in the number of splenic CD19+ve B cells and ratio of CD19:CD3 cells, (p<0.05) with no change in the T cell population. Myeloperoxidase assay showed reduced macrophages in the kidney. However, a significant reduction in M2 subset of splenic macrophages by apoferritin was prevented by curcumin, suggesting a protective function. Curcumin treatment reduced mRNA expression of inflammatory proteins MCP-1 and TGFβ and matrix proteins, fibronectin, laminin and collagen. Our results clearly illustrate that curcumin reduces glomerulosclerosis, improves kidney function and could serve as a therapeutic agent during serum sickness. © 2013 The Authors. Immunology © 2013 Blackwell Publishing Ltd.
Authors:
Alexander Jacob; Lee Chaves; Michael T Eadon; Anthony Chang; Richard J Quigg; Jessy J Alexander
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-24
Journal Detail:
Title:  Immunology     Volume:  -     ISSN:  1365-2567     ISO Abbreviation:  Immunology     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0374672     Medline TA:  Immunology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2013 The Authors. Immunology © 2013 Blackwell Publishing Ltd.
Affiliation:
Department of Medicine, The University of Chicago, Chicago, Illinois.
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