Document Detail


Curcumin ameliorates arterial dysfunction and oxidative stress with aging.
MedLine Citation:
PMID:  23142245     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We tested the hypothesis that curcumin supplementation would reverse arterial dysfunction and vascular oxidative stress with aging. Young (Y, 4-6 months) and old (O, 26-28 months) male C57BL6/N mice were given normal or curcumin supplemented (0.2%) chow for 4 weeks (n=5-10/group/measure). Large elastic artery stiffness, assessed by aortic pulse wave velocity (aPWV), was greater in O (448±15 vs. 349±15 cm/s) and associated with greater collagen I and advanced glycation end-products and less elastin (all P<0.05). In O, curcumin restored aPWV (386±15 cm/s), collagen I and AGEs (AGEs) to levels not different vs. Y. Ex vivo carotid artery acetylcholine (ACh)-induced endothelial-dependent dilation (EDD, 79±3 vs. 94±2%), nitric oxide (NO) bioavailability and protein expression of endothelial NO synthase (eNOS) were lower in O (all P<0.05). In O, curcumin restored NO-mediated EDD (92±2%) to levels of Y. Acute ex vivo administration of the superoxide dismutase (SOD) mimetic TEMPOL normalized EDD in O control mice (93±3%), but had no effect in Y control or O curcumin treated animals. O had greater arterial nitrotyrosine abundance, superoxide production and NADPH oxidase p67 subunit expression, and lower manganese SOD (all P<0.05), all of which were reversed with curcumin. Curcumin had no effects on Y. Curcumin supplementation ameliorates age-associated large elastic artery stiffening, NO-mediated vascular endothelial dysfunction, oxidative stress and increases in collagen and AGEs in mice. Curcumin may be a novel therapy for treating arterial aging in humans.
Authors:
Bradley S Fleenor; Amy L Sindler; Natasha K Marvi; Kate L Howell; Melanie L Zigler; Mutsuko Yoshizawa; Douglas R Seals
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-11-07
Journal Detail:
Title:  Experimental gerontology     Volume:  48     ISSN:  1873-6815     ISO Abbreviation:  Exp. Gerontol.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-28     Completed Date:  2013-07-08     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  0047061     Medline TA:  Exp Gerontol     Country:  England    
Other Details:
Languages:  eng     Pagination:  269-76     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Aging / metabolism*
Animals
Antioxidants / pharmacology*
Aorta / drug effects*,  metabolism,  physiopathology
Carotid Arteries / drug effects*,  metabolism,  physiopathology
Collagen Type I / metabolism
Curcumin / pharmacology*
Dose-Response Relationship, Drug
Elastin / metabolism
Endothelium, Vascular / drug effects,  metabolism,  physiopathology
Glycosylation End Products, Advanced / metabolism
Male
Mice
Mice, Inbred C57BL
Nitric Oxide / metabolism
Nitric Oxide Synthase Type III / metabolism
Oxidative Stress / drug effects*
Phosphoproteins / metabolism
Pulse Wave Analysis
Superoxide Dismutase / metabolism
Superoxides / metabolism
Tyrosine / analogs & derivatives,  metabolism
Vascular Stiffness / drug effects*
Vasodilation / drug effects
Vasodilator Agents / pharmacology
Grant Support
ID/Acronym/Agency:
AG000279/AG/NIA NIH HHS; AG13038/AG/NIA NIH HHS; HL007822/HL/NHLBI NIH HHS; R37 AG013038/AG/NIA NIH HHS; T32 AG000279/AG/NIA NIH HHS; T32 HL007822/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Collagen Type I; 0/Glycosylation End Products, Advanced; 0/Phosphoproteins; 0/Vasodilator Agents; 0/neutrophil cytosol factor 67K; 11062-77-4/Superoxides; 31C4KY9ESH/Nitric Oxide; 3604-79-3/3-nitrotyrosine; 42HK56048U/Tyrosine; 9007-58-3/Elastin; EC 1.14.13.39/Nitric Oxide Synthase Type III; EC 1.14.13.39/Nos3 protein, mouse; EC 1.15.1.1/Superoxide Dismutase; IT942ZTH98/Curcumin
Comments/Corrections

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