| Curcumin Ameliorates Arterial Dysfunction and Oxidative Stress with Aging. | |
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MedLine Citation:
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PMID: 23142245 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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We tested the hypothesis that curcumin supplementation would reverse arterial dysfunction and vascular oxidative stress with aging. Young (Y, 4-6 mo) and old (O, 26-28 mo) male C57BL6/N mice were given normal or curcumin supplemented (0.2%) chow for 4weeks (n=5-10/group/measure). Large elastic artery stiffness, assessed by aortic pulse wave velocity (aPWV), was greater in O (448±15 vs. 349±15cm/s) and associated with greater collagen I and advanced glycation end-products and less elastin (all P<0.05). In O, curcumin restored aPWV (386±15cm/s), collagen I and AGEs to levels not different vs. Y. Ex vivo carotid artery acetylcholine (ACh)-induced endothelial-dependent dilation (EDD, 79±3 vs. 94±2%), nitric oxide (NO) bioavailability and protein expression of endothelial NO synthase (eNOS) were lower in O (all P<0.05). In O, curcumin restored NO-mediated EDD (92±2%) to levels of Y. Acute ex vivo administration of the superoxide dismutase (SOD) mimetic TEMPOL normalized EDD in O control mice (93±3%), but had no effect in Y control or O curcumin treated animals. O had greater arterial nitrotyrosine abundance, superoxide production and NADPH oxidase p67 subunit expression, and lower manganese SOD (all P<0.05), all of which were reversed with curcumin. Curcumin had no effects on Y. Curcumin supplementation ameliorates age-associated large elastic artery stiffening, NO-mediated vascular endothelial dysfunction, oxidative stress and increases in collagen and AGEs in mice. Curcumin may be a novel therapy for treating arterial aging in humans. |
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Authors:
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Bradley S Fleenor; Amy L Sindler; Natasha K Marvi; Kate L Howell; Melanie L Zigler; Mutsuko Yoshizawa; Douglas R Seals |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-11-7 |
Journal Detail:
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Title: Experimental gerontology Volume: - ISSN: 1873-6815 ISO Abbreviation: Exp. Gerontol. Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2012-11-12 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0047061 Medline TA: Exp Gerontol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012. Published by Elsevier Inc. |
Affiliation:
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Department of Integrative Physiology, University of Colorado, Boulder, CO, 80309, USA. Electronic address: bradley.fleenor@uky.edu. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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