| Cuprophan reuse and intradialytic changes of lung diffusion capacity and blood gases. | |
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MedLine Citation:
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PMID: 3626294 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The changes in arterial blood gas, pulmonary function tests, leukocyte counts and complement activation were evaluated during first use and subsequent reuse of cuprophan dialyzers. The dialysate buffer was bicarbonate. Reuse of cuprophan dialyzers significantly attenuated the fall in leukocyte counts and the rise in C3a des Arg seen during first use dialysis. First use dialysis also caused a drop in arterial paO2 from 93.0 +/- 12.4 mm Hg to a nadir of 82.8 +/- 12.6 mm Hg at 60 minutes (P less than 0.01). PaO2 levels did not change when reused dialyzers were employed (93.7 +/- 12.2 before dialysis and 96.4 +/- 15.2 mm Hg at 60 minutes, P greater than 0.05). Intradialytic paO2 curves obtained during first use and reuse were significantly different by variance analysis (P less than 0.001). There was also a significant decline in lung diffusion capacity (DLCO, from 30.70 +/- 8.89 to 23.77 +/- 7.76 ml/min X mm Hg, P less than 0.01) and transfer factor (KCO, from 6.07 +/- 1.97 to 5.65 +/- 2.13 ml/min X mm Hg, P less than 0.01), during first use at one hour after initiation of dialysis. This decrease was entirely prevented during reuse, (P less than 0.001 vs. first use by variance analysis). Percentual changes in leukocyte counts and C3a des Arg concentration on one hand, and in paO2, DLCO and KCO on the other were significantly correlated to each other. Other factors with a possible influence on intradialytic pulmonary function such as ultrafiltration volume, dialysate buffer composition, evolution of intradialytic blood pH and cardiac output, were all identical under both experimental conditions.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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R C Vanholder; R A Pauwels; J F Vandenbogaerde; H H Lamont; M E Van der Straeten; S M Ringoir |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Kidney international Volume: 32 ISSN: 0085-2538 ISO Abbreviation: Kidney Int. Publication Date: 1987 Jul |
Date Detail:
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Created Date: 1987-10-21 Completed Date: 1987-10-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0323470 Medline TA: Kidney Int Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 117-22 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Analysis of Variance Blood Gas Analysis Cellulose / analogs & derivatives* Female Humans Leukocyte Count Lung / physiopathology* Male Membranes, Artificial* Middle Aged Renal Dialysis / adverse effects* Respiratory Function Tests |
| Chemical | |
Reg. No./Substance:
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0/Membranes, Artificial; 9004-34-6/Cellulose; 9050-09-3/cuprammonium cellulose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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