Document Detail

Cumulus cell-oocyte complexes retrieved from antral follicles in IVM cycles: relationship between COCs morphology, gonadotropin priming and clinical outcome.
MedLine Citation:
PMID:  22527899     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To assess retrospectively the developmental potential of different types of cumulus cell-oocyte complexes (COCs) derived from IVM cycles.
METHODS: IVM cycles were performed in natural cycles or after HCG, FSH, or FSH/HCG priming. COCs recovered were morphologically characterized in different types: compact (CC) or expanded (EC) cumulus mass but including an immature oocyte, and expanded cumulus mass enclosing a mature oocyte (EC-MII). Embryo developmental competence was investigated analysing exclusively cycles in which all transferred embryos derived from the same COC category.
RESULTS: Fertilization rates did not differ significantly. Significant differences in pregnancy rates (14.5%, 10.0% and 27.6 % in the CC, EC, and EC-MII categories, respectively) were observed. Likewise, significant differences in implantation rates (8.9%, 6.3% and 19.1% in the CC, EC, and EC-MII categories, respectively) were found. Overall, priming with FSH/HCG had a beneficial effect on pregnancy and implantation rates, while no priming or HCG alone generated oocytes with poor competence.
CONCLUSIONS: In IVM cycles, morphological evaluation at the time of collection can predict the developmental ability of different COCs. FSH/HGC priming has a positive effect on oocyte competence.
Mariabeatrice Dal Canto; Fausta Brambillasca; Mario Mignini Renzini; Giovanni Coticchio; Maria Merola; Monia Lain; Elena De Ponti; Rubens Fadini
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Publication Detail:
Type:  Clinical Trial; Journal Article     Date:  2012-04-18
Journal Detail:
Title:  Journal of assisted reproduction and genetics     Volume:  29     ISSN:  1573-7330     ISO Abbreviation:  J. Assist. Reprod. Genet.     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-06-08     Completed Date:  2012-11-30     Revised Date:  2013-06-25    
Medline Journal Info:
Nlm Unique ID:  9206495     Medline TA:  J Assist Reprod Genet     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  513-9     Citation Subset:  IM    
Biogenesi Reproductive Medicine Centre, Istituti Clinici Zucchi, V Zucchi 24, Monza, Italy.
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MeSH Terms
Chorionic Gonadotropin / pharmacology*,  therapeutic use
Cumulus Cells / cytology*,  physiology
Embryo Transfer
Embryonic Development
Fertilization in Vitro*
Follicle Stimulating Hormone / pharmacology*,  therapeutic use
Oocytes / cytology*,  drug effects,  physiology
Ovarian Follicle / cytology*,  drug effects*
Pregnancy Rate
Retrospective Studies
Treatment Outcome
Reg. No./Substance:
0/Chorionic Gonadotropin; 9002-68-0/Follicle Stimulating Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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