Document Detail

Cumulative probability of live birth after three in vitro fertilization/intracytoplasmic sperm injection cycles.
MedLine Citation:
PMID:  11872203     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To assess the probability of live birth after three available in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) cycles. DESIGN: Retrospective, observational study. SETTING: University hospital. PATIENT(S): Nine hundred seventy-four couples who started their first conventional IVF or ICSI cycle between January 1996 and December 1997. A total of 1985 stimulated cycles were initiated. INTERVENTION(S): Analysis of the cumulative live birth rate using the life-table approach with and without taking dropouts into account. MAIN OUTCOME MEASURE(S): Cumulative live birth rate. RESULT(S): The overall cumulative live birth rate after three completed stimulated cycles (including freezing/thawing cycles) was 65.5% with an "optimistic" approach. For the "realistic" and "pessimistic" approaches the corresponding figures were 63.1% and 55.5%, respectively. Unexpectedly, 65% of couples not achieving a live birth interrupted the full treatment program of three cycles. CONCLUSION(S): The cumulative live birth rate gives the couple a more accurate prognosis of achieving a live birth after IVF/ICSI than the statistics usually provided. With the "realistic" estimation, 63% of the couples achieved childbirth after three available conventional IVF or ICSI cycles. Further studies are required to investigate the high drop-out rate.
Katarina Olivius; Barbro Friden; Kersti Lundin; Christina Bergh
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Fertility and sterility     Volume:  77     ISSN:  0015-0282     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2002 Mar 
Date Detail:
Created Date:  2002-03-01     Completed Date:  2002-04-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  505-10     Citation Subset:  IM    
Center for Reproductive Medicine, Sahlgrenska University Hospital, Göteborg University, Göteborg, Sweden.
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MeSH Terms
Birth Rate*
Cohort Studies
Infertility / therapy*
Life Tables
Ovulation Induction*
Patient Dropouts
Pregnancy Outcome
Retrospective Studies
Sperm Injections, Intracytoplasmic*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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