| Cumulative pregnancy rate following IVF and intracytoplasmatic sperm injection with ejaculated and testicular spermatozoa. | |
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MedLine Citation:
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PMID: 12470578 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of this study was to calculate the cumulative pregnancy rates of IVF cycles with ICSI using ejaculated or testicular spermatozoa. A computerized database for the IVF cycles with ICSI performed between January 1996 and December 1998 was utilized. Cycles with spermatozoa obtained after electro-ejaculation were excluded. A multifactorial analysis was performed to define the impact of different factors on the success rate of IVF and ICSI. During a 36-month period, 229 pregnancies were achieved by 643 couples using ejaculated spermatozoa, and 83 pregnancies by 167 couples who required testicular spermatozoa. The pregnancy rates (PR) per cycle, including all treatment cycles with ejaculated spermatozoa, remained similar during the first five consecutive cycles achieving a cumulative PR of 80.44%. The cumulative pregnancy rates for cycles with testicular spermatozoa showed a consistent rise during four consecutive treatments and reached 61.84%. The regression analysis of pregnancy rate showed that it was significantly positively correlated with oocyte fertilization rate (P = 0.02), and negatively correlated with maternal age (P = 0.03). Thus, according to the present results, couples with infertility who require IVF with ICSI should be offered at least five consecutive attempts if ejaculated spermatozoa are used, and at least four cycles whenever testicular spermatozoa are used. |
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Authors:
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Adrian Shulman; Kfir Menashe; Arie Laor; Jacob Levron; Ygal Madgar; David Bider; Yaron Rabinovitz; Daniel Seidman; Gil Raviv; Shlomo Maschiach; Jehoshua Dor |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Reproductive biomedicine online Volume: 4 ISSN: 1472-6483 ISO Abbreviation: Reprod. Biomed. Online Publication Date: 2002 Mar-Apr |
Date Detail:
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Created Date: 2002-12-09 Completed Date: 2002-12-30 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 101122473 Medline TA: Reprod Biomed Online Country: England |
Other Details:
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Languages: eng Pagination: 151-6 Citation Subset: IM |
Affiliation:
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The IVF Unit, Department of Obstetrics and Gynecology, The Chaim Sheba Medical Centre, Tel Hashomer, (affiliated with Sackler Faculty of Medicine, Tel Aviv University), Israel. adrian@netvision.net.il |
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| MeSH Terms | |
Descriptor/Qualifier:
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Ejaculation* Female Fertilization in Vitro* Humans Male Oligospermia / therapy Pregnancy Pregnancy Rate* Regression Analysis Sperm Injections, Intracytoplasmic* Testis / cytology* Tissue and Organ Harvesting / methods |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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