Document Detail

Cumulative perinatal steroids: child development of preterm infants.
MedLine Citation:
PMID:  18492549     Owner:  NLM     Status:  MEDLINE    
The development of premature infants may be altered due to exposure to high cumulative doses of the perinatal corticosteroid dexamethasone during critical growth periods. To compare child behavioral development of prematurely born infants who were exposed to higher perinatal steroids (PNS; >0.2 mg/kg) with that of infants exposed to lower PNS (<or=0.2 mg/kg), we used the Vineland Adaptive Behavioral Scales to assess school-age behavioral outcomes of a historical cohort of 45 prematurely born infants. Children who had received higher PNS treatment were more likely to have lower overall behavioral developmental scores, especially lower social skills (p < .05). Higher PNS plus higher severity of illness during the first day of life based on the Clinical Risk Index for Babies (p = .016) and lower birth head size (p = .015) were linked with poorer behavioral outcomes among participants. Nursing practice includes promotion of quality care and should include closer evaluation of cumulative steroid therapy, severity of illness, and promotion of long-term follow-up support for premature infants.
Isabell B Purdy; Dorothy J Wiley; Lynne M Smith; Carollee Howes; Anna Gawlinski; Wendy Robbins; Lina K Badr
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pediatric nursing     Volume:  23     ISSN:  1532-8449     ISO Abbreviation:  J Pediatr Nurs     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-05-21     Completed Date:  2008-07-11     Revised Date:  2013-06-05    
Medline Journal Info:
Nlm Unique ID:  8607529     Medline TA:  J Pediatr Nurs     Country:  United States    
Other Details:
Languages:  eng     Pagination:  201-14     Citation Subset:  IM; N    
University of California, Los Angeles, CA 90095-1752, USA.
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MeSH Terms
Analysis of Variance
Chi-Square Distribution
Developmental Disabilities / chemically induced*,  diagnosis,  epidemiology*
Dexamethasone / administration & dosage,  adverse effects*
Glucocorticoids / administration & dosage,  adverse effects*
Infant, Newborn
Intensive Care, Neonatal
Obstetric Labor, Premature / drug therapy*
Parents / psychology
Perinatal Care
Prospective Studies
Regression Analysis
Risk Factors
Severity of Illness Index
Treatment Outcome
Grant Support
T32 NR007077-05/NR/NINR NIH HHS
Reg. No./Substance:
0/Glucocorticoids; 50-02-2/Dexamethasone

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