| Cumulative perinatal steroids: child development of preterm infants. | |
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MedLine Citation:
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PMID: 18492549 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The development of premature infants may be altered due to exposure to high cumulative doses of the perinatal corticosteroid dexamethasone during critical growth periods. To compare child behavioral development of prematurely born infants who were exposed to higher perinatal steroids (PNS; >0.2 mg/kg) with that of infants exposed to lower PNS (<or=0.2 mg/kg), we used the Vineland Adaptive Behavioral Scales to assess school-age behavioral outcomes of a historical cohort of 45 prematurely born infants. Children who had received higher PNS treatment were more likely to have lower overall behavioral developmental scores, especially lower social skills (p < .05). Higher PNS plus higher severity of illness during the first day of life based on the Clinical Risk Index for Babies (p = .016) and lower birth head size (p = .015) were linked with poorer behavioral outcomes among participants. Nursing practice includes promotion of quality care and should include closer evaluation of cumulative steroid therapy, severity of illness, and promotion of long-term follow-up support for premature infants. |
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Authors:
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Isabell B Purdy; Dorothy J Wiley; Lynne M Smith; Carollee Howes; Anna Gawlinski; Wendy Robbins; Lina K Badr |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of pediatric nursing Volume: 23 ISSN: 1532-8449 ISO Abbreviation: J Pediatr Nurs Publication Date: 2008 Jun |
Date Detail:
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Created Date: 2008-05-21 Completed Date: 2008-07-11 Revised Date: 2013-06-05 |
Medline Journal Info:
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Nlm Unique ID: 8607529 Medline TA: J Pediatr Nurs Country: United States |
Other Details:
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Languages: eng Pagination: 201-14 Citation Subset: IM; N |
Affiliation:
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University of California, Los Angeles, CA 90095-1752, USA. ipurdy@mednet.ucla.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Analysis of Variance Anthropometry Chi-Square Distribution Child Developmental Disabilities / chemically induced*, diagnosis, epidemiology* Dexamethasone / administration & dosage, adverse effects* Female Glucocorticoids / administration & dosage, adverse effects* Humans Infant, Newborn Intensive Care, Neonatal Male Morbidity Obstetric Labor, Premature / drug therapy* Parents / psychology Perinatal Care Pregnancy Prospective Studies Questionnaires Regression Analysis Risk Factors Severity of Illness Index Treatment Outcome |
| Grant Support | |
ID/Acronym/Agency:
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T32 NR007077-05/NR/NINR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Glucocorticoids; 50-02-2/Dexamethasone |
| Comments/Corrections | |
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