Document Detail


Cumulative live birth rates following IVF in 41- to 43-year-old women presenting with favourable ovarian reserve characteristics.
MedLine Citation:
PMID:  17425827     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
For women aged 41-43 years old, success rates in IVF are generally poor. This study aimed to assess cumulative live birth rate related to treatment costs over a maximum of three IVF cycles in selected women who were considered to still have adequate ovarian reserve. Fifty-five patients (38% of the total cohort, n = 144) were excluded from IVF treatment based on low antral follicle count (<5 follicles) and/or elevated basal FSH (>15 IU/l). Of those admitted, 66 (74%) actually started and completed a total of 125 IVF/intracytoplasmic sperm injection cycles. Treatment resulted in 10 live births (8% per cycle). Kaplan-Meier survival analysis revealed a realistic cumulative live birth rate after three cycles of 17%. The direct medical costs per live birth were calculated to be approximately 44,000 euro. These results show that selection towards favourable ovarian reserve status in the female age group 41-43 years yielded disappointing results in terms of cumulative live birth rates after IVF. In view of the costs raised per live birth, improvement of selection parameters for treatment in this age group is warranted.
Authors:
J van Disseldorp; M J C Eijkemans; E R Klinkert; E R te Velde; B C Fauser; F J M Broekmans
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Reproductive biomedicine online     Volume:  14     ISSN:  1472-6483     ISO Abbreviation:  Reprod. Biomed. Online     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-04-11     Completed Date:  2007-05-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101122473     Medline TA:  Reprod Biomed Online     Country:  England    
Other Details:
Languages:  eng     Pagination:  455-63     Citation Subset:  IM    
Affiliation:
Department of Reproductive Medicine and Gynaecology, University Medical Centre Utrecht, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Adult
Birth Rate
Cohort Studies
Female
Fertilization in Vitro / methods*
Follicle Stimulating Hormone / metabolism*
Humans
Live Birth
Ovarian Follicle / pathology*,  physiology
Ovary / pathology*,  physiology
Pregnancy
Pregnancy Outcome
Pregnancy Rate
Retrospective Studies
Sperm Injections, Intracytoplasmic / methods*
Chemical
Reg. No./Substance:
9002-68-0/Follicle Stimulating Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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