Document Detail

Cumulative first live birth after elective cryopreservation of all embryos due to ovarian hyperresponsiveness.
MedLine Citation:
PMID:  14967365     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To estimate cumulative chance for first live birth after elective pronuclear stage cryopreservation of all embryos due to ovarian hyperresponsiveness. DESIGN: Retrospective analysis with longitudinal follow-up. SETTING: Academic hospital. PATIENT(S): Thirty subjects with elective cryopreservation of all embryos due to ovarian hyperresponsiveness. INTERVENTION(S): Elective cryopreservation of all embryos at the pronuclear stage (n = 30) and subsequent cryopreserved-thawed ET (n = 51). MAIN OUTCOME MEASURE(S): Cumulative chance for first live birth. RESULT(S): Cumulative chance for first live birth was 77% when analyzed by intention to treat and 82% by treatment with ET. Nearly 40% of live births were multiple. CONCLUSION(S): Cumulative first live birth increased with repetitive ET after elective pronuclear stage cryopreservation of all embryos due to ovarian hyperresponsiveness. Multiple births, however, were frequent. In the context of initial ET attempts in young women, transfer of no more than two cryopreserved-thawed embryos is advised.
Ian S Tummon; Stephen A Contag; Alan R Thornhill; Donna R Session; Daniel A Dumesic; Mark A Damario
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Fertility and sterility     Volume:  81     ISSN:  0015-0282     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2004 Feb 
Date Detail:
Created Date:  2004-02-17     Completed Date:  2004-03-24     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  309-14     Citation Subset:  IM    
Mayo Clinic, Rochester, Minnesota 55905, USA.
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MeSH Terms
Chorionic Gonadotropin / blood
Cryopreservation / methods*
Embryo Transfer
Embryo, Mammalian*
Estradiol / blood
Fertilization in Vitro / methods*
Follow-Up Studies
Infant, Newborn
Longitudinal Studies
Oocytes / cytology
Ovarian Hyperstimulation Syndrome / physiopathology*
Pregnancy Outcome*
Retrospective Studies
Time Factors
Reg. No./Substance:
0/Chorionic Gonadotropin; 50-28-2/Estradiol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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