Document Detail


Cumulative effects of high cholesterol levels, high blood pressure, and cigarette smoking on carotid stenosis.
MedLine Citation:
PMID:  9262494     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Single measurements of cardiovascular risk factors may not accurately reflect a person's past exposure to those risk factors. We therefore studied the long-term associations of cardiovascular risk factors such as high serum cholesterol levels, high blood pressure, and cigarette smoking with the prevalence of carotid stenosis. METHODS: We studied cross-sectional and longitudinal information from a sample of 429 men and 661 women in the Framingham Heart Study who underwent B-mode ultrasound measurements of the carotid artery. Their mean age was 75 years, and each had attended most of the biennial clinic examinations over the 34 years before the carotid ultrasound study. We used time-integrated measurements to assess the associations between various cardiovascular risk factors and the degree of carotid stenosis. RESULTS: Moderate carotid stenosis (> or =25 percent) was present in 189 men and 226 women. We assessed the odds ratios for this degree of stenosis as compared with minimal stenosis (<25 percent) according to increases in risk factors. In the men, the odds ratio for moderate carotid stenosis associated with an increase of 20 mm Hg in systolic blood pressure was 2.11 (95 percent confidence interval, 1.51 to 2.97). The odds ratio for an increase of 10 mg per deciliter (0.26 mmol per liter) in the cholesterol level was 1.10 (95 percent confidence interval, 1.03 to 1.16), and for an increase of five pack-years of smoking it was 1.08 (95 percent confidence interval, 1.03 to 1.13). The results were similar in the women. Time-integrated measurements of diastolic blood pressure showed significant associations with carotid stenosis in men and insignificant associations in women. CONCLUSIONS: Over the long term, high systolic blood pressure, high cholesterol levels, and smoking were associated with an increased risk of carotid stenosis in this elderly population.
Authors:
P W Wilson; J M Hoeg; R B D'Agostino; H Silbershatz; A M Belanger; H Poehlmann; D O'Leary; P A Wolf
Related Documents :
1859294 - Predictors of intracranial carotid artery atherosclerosis. duration of cigarette smokin...
18370804 - Agreement of two metabolic syndrome definitions and their association with subclinical ...
19037584 - Association of breast arterial calcification and carotid intima-media thickness.
17186134 - Carotid artery intima media thickness, plaque and framingham cardiovascular score in as...
19195714 - Antibiotics versus placebo in the treatment of women with uncomplicated cystitis: a met...
15614964 - World aids day, december 1: women and girls.
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The New England journal of medicine     Volume:  337     ISSN:  0028-4793     ISO Abbreviation:  N. Engl. J. Med.     Publication Date:  1997 Aug 
Date Detail:
Created Date:  1997-08-21     Completed Date:  1997-08-21     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0255562     Medline TA:  N Engl J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  516-22     Citation Subset:  AIM; IM    
Affiliation:
Framingham Heart Study, National Heart, Lung, and Blood Institute, MA 01701, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aged
Carotid Stenosis / etiology*
Cross-Sectional Studies
Female
Humans
Hypercholesterolemia / complications*
Hypertension / complications*
Longitudinal Studies
Male
Odds Ratio
Regression Analysis
Risk Factors
Smoking / adverse effects*
Systole
Grant Support
ID/Acronym/Agency:
5R01-NS17950/NS/NINDS NIH HHS; N01-HC-38038/HC/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The acquisition of herpes simplex virus during pregnancy.
Next Document:  The effect of calcium supplementation on bone density during lactation and after weaning.