| Cumulative alterations of p27-related cell-cycle regulators in the development of endometriosis-associated ovarian clear cell adenocarcinoma. | |
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MedLine Citation:
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PMID: 20546339 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: To identify the key cell-cycle dysregulations in the development of endometriosis-associated ovarian clear cell adenocarcinoma (CCA). METHODS AND RESULTS: Expression of p27(Kip1)-interacting cell-cycle regulators, such as p27(Kip1) itself, Skp2, cyclin-dependent kinase subunit 1 (Cks1), cyclin A and cyclin E, and Ki67 labelling index (LI), were analysed by immunohistochemistry in 23 CCAs with 36 endometriotic or atypical endometriotic lesions adjacent to CCA from a cohort of 23 patients, and in 31 cases of solitary endometriosis. The cell-cycle regulators examined were overexpressed (Skp2, Cks1, cyclin A and cyclin E; P < 0.01, each) or down-regulated (p27(Kip1), P = 0.044) significantly more frequently in the CCAs than in the adjacent endometriosis. The frequency of Skp2 overexpression was significantly higher in atypical endometriosis than in endometriosis, and the frequency of Skp2 and cyclin A overexpression was significantly higher in CCA than in atypical endometriosis (P < 0.01, each). Mean Ki67 LI increased from endometriosis (8.4%) through atypical endometriosis (21.4%) to CCA (46.9%), with statistical significance between each component (P < 0.01, each). The frequency of cell-cycle regulator expression and mean Ki67 LIs were not significantly different between solitary endometriosis and endometriosis adjacent to CCA. CONCLUSIONS: Alteration of the p27(Kip1)-interacting cell-cycle regulators appeared strongly involved in the progression of endometriosis-associated ovarian clear cell carcinogenesis through increasing cell proliferative activity. |
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Authors:
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Sohei Yamamoto; Hitoshi Tsuda; Kosuke Miyai; Masashi Takano; Seiichi Tamai; Osamu Matsubara |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Histopathology Volume: 56 ISSN: 1365-2559 ISO Abbreviation: Histopathology Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-06-15 Completed Date: 2010-11-03 Revised Date: 2012-06-19 |
Medline Journal Info:
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Nlm Unique ID: 7704136 Medline TA: Histopathology Country: England |
Other Details:
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Languages: eng Pagination: 740-9 Citation Subset: IM |
Affiliation:
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Department of Basic Pathology, National Defence Medical College, Tokorozawa, Saitama, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma, Clear Cell
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etiology,
metabolism*,
pathology Carrier Proteins / metabolism Cell Cycle Proteins / metabolism* Cyclin A / metabolism Cyclin-Dependent Kinase Inhibitor p27 Cyclin-Dependent Kinases / metabolism Down-Regulation Endometriosis / complications*, genetics, pathology Female Humans Intracellular Signaling Peptides and Proteins / metabolism* Ovarian Neoplasms / etiology, metabolism*, pathology S-Phase Kinase-Associated Proteins / metabolism |
| Chemical | |
Reg. No./Substance:
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0/CDKN1B protein, human; 0/CKS1B protein, human; 0/Carrier Proteins; 0/Cell Cycle Proteins; 0/Cyclin A; 0/Intracellular Signaling Peptides and Proteins; 0/S-Phase Kinase-Associated Proteins; 147604-94-2/Cyclin-Dependent Kinase Inhibitor p27; EC 2.7.11.22/Cyclin-Dependent Kinases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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