Document Detail

Cumulative alterations of p27-related cell-cycle regulators in the development of endometriosis-associated ovarian clear cell adenocarcinoma.
MedLine Citation:
PMID:  20546339     Owner:  NLM     Status:  MEDLINE    
AIMS: To identify the key cell-cycle dysregulations in the development of endometriosis-associated ovarian clear cell adenocarcinoma (CCA).
METHODS AND RESULTS: Expression of p27(Kip1)-interacting cell-cycle regulators, such as p27(Kip1) itself, Skp2, cyclin-dependent kinase subunit 1 (Cks1), cyclin A and cyclin E, and Ki67 labelling index (LI), were analysed by immunohistochemistry in 23 CCAs with 36 endometriotic or atypical endometriotic lesions adjacent to CCA from a cohort of 23 patients, and in 31 cases of solitary endometriosis. The cell-cycle regulators examined were overexpressed (Skp2, Cks1, cyclin A and cyclin E; P < 0.01, each) or down-regulated (p27(Kip1), P = 0.044) significantly more frequently in the CCAs than in the adjacent endometriosis. The frequency of Skp2 overexpression was significantly higher in atypical endometriosis than in endometriosis, and the frequency of Skp2 and cyclin A overexpression was significantly higher in CCA than in atypical endometriosis (P < 0.01, each). Mean Ki67 LI increased from endometriosis (8.4%) through atypical endometriosis (21.4%) to CCA (46.9%), with statistical significance between each component (P < 0.01, each). The frequency of cell-cycle regulator expression and mean Ki67 LIs were not significantly different between solitary endometriosis and endometriosis adjacent to CCA.
CONCLUSIONS: Alteration of the p27(Kip1)-interacting cell-cycle regulators appeared strongly involved in the progression of endometriosis-associated ovarian clear cell carcinogenesis through increasing cell proliferative activity.
Sohei Yamamoto; Hitoshi Tsuda; Kosuke Miyai; Masashi Takano; Seiichi Tamai; Osamu Matsubara
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Histopathology     Volume:  56     ISSN:  1365-2559     ISO Abbreviation:  Histopathology     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-06-15     Completed Date:  2010-11-03     Revised Date:  2012-06-19    
Medline Journal Info:
Nlm Unique ID:  7704136     Medline TA:  Histopathology     Country:  England    
Other Details:
Languages:  eng     Pagination:  740-9     Citation Subset:  IM    
Department of Basic Pathology, National Defence Medical College, Tokorozawa, Saitama, Japan.
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MeSH Terms
Adenocarcinoma, Clear Cell / etiology,  metabolism*,  pathology
Carrier Proteins / metabolism
Cell Cycle Proteins / metabolism*
Cyclin A / metabolism
Cyclin-Dependent Kinase Inhibitor p27
Cyclin-Dependent Kinases / metabolism
Endometriosis / complications*,  genetics,  pathology
Intracellular Signaling Peptides and Proteins / metabolism*
Ovarian Neoplasms / etiology,  metabolism*,  pathology
S-Phase Kinase-Associated Proteins / metabolism
Reg. No./Substance:
0/CDKN1B protein, human; 0/CKS1B protein, human; 0/Carrier Proteins; 0/Cell Cycle Proteins; 0/Cyclin A; 0/Intracellular Signaling Peptides and Proteins; 0/S-Phase Kinase-Associated Proteins; 147604-94-2/Cyclin-Dependent Kinase Inhibitor p27; EC Kinases

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