| Cumulative patient effective dose and acute radiation-induced chromosomal DNA damage in children with congenital heart disease. | |
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MedLine Citation:
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PMID: 19687017 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The seventh Committee on "Biological Effects of Ionizing Radiation" (BEIR VII, 2006) underlines "the need of studies of infants who are exposed to diagnostic radiation because catheters have been placed in their hearts". OBJECTIVE: To determine the lifetime attributable risk (LAR) of cancer associated with the estimated cumulative radiological dose in 59 children (42 male, age 2.8+/-3.2 years) with complex congenital heart disease, and to assess chromosomal DNA damage after cardiac catheterisation procedures. Methods In all patients, the cumulative exposure was estimated as effective dose in milliSievert (mSv), and LAR cancer was determined from the BEIR VII report. In a subset of 18 patients (13 male, age 5.2+/-5.7 years) micronucleus as a biomarker of DNA damage and long-term risk predictor of cancer was assayed before and 2 h after catheterisation procedures. Dose-area product (Gy cm(2)) was assessed as a measure of patient dose. RESULTS: The median life time cumulative effective dose was 7.7 mSv per patient (range 4.6-41.2). Cardiac catheterisation procedures and CT were responsible for 95% of the total effective dose. For a 1-year-old child, the LAR cancer was 1 in 382 (25th to 75th centiles: 1 in 531 to 1 in 187) and 1 in 156 (25th to 75th centiles: 1 in 239 to 1 in 83) for male and female patients, respectively. Median micronucleus values increased significantly after the procedure in comparison with baseline (before 6 per thousand vs after 9 per thousand, p=0.02). The median dose-area product value was 20 Gy cm(2) (range 1-277). CONCLUSION: Children with congenital heart disease are exposed to a significant cumulative dose. Indirect cancer risk estimations and direct DNA data both emphasise the need for strict radiation dose optimisation in children. |
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Authors:
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Lamia Ait-Ali; Maria Grazia Andreassi; Ilenia Foffa; Isabella Spadoni; Eliseo Vano; Eugenio Picano |
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Publication Detail:
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Type: Journal Article Date: 2009-08-16 |
Journal Detail:
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Title: Heart (British Cardiac Society) Volume: 96 ISSN: 1468-201X ISO Abbreviation: Heart Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-03-02 Completed Date: 2010-04-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9602087 Medline TA: Heart Country: England |
Other Details:
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Languages: eng Pagination: 269-74 Citation Subset: AIM; IM |
Affiliation:
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CNR Institute of Clinical Physiology, G Pasquinucci Hospital, Via Aurelia Sud-Montepepe, 54100 Massa, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Child Child, Preschool DNA / radiation effects DNA Damage* Female Heart Catheterization / adverse effects Heart Defects, Congenital / radiography* Humans Infant Male Neoplasms, Radiation-Induced / etiology* Radiation Dosage Radiation Injuries / etiology* Risk Factors |
| Chemical | |
Reg. No./Substance:
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9007-49-2/DNA |
| Comments/Corrections | |
Comment In:
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Heart. 2010 Feb;96(4):251-2
[PMID:
19875368
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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