Document Detail


Cultured human and rat tooth papilla cells induce hair follicle regeneration and fiber growth.
MedLine Citation:
PMID:  15617567     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The mesenchymal-epithelial interactions that characterize the early stages of tooth and hair follicle morphogenesis share certain similarities, and there is increasing evidence that mesenchymal cells derived from both mature structures retain interactive and stem cell-like properties. This study aimed to gauge the cross-appendage inductive capabilities of cultured tooth dental papilla (or pulp) cells from different species and ages of donor. Adult human and juvenile rat tooth papilla cells were implanted into surgically inactivated hair follicles within two different microenvironments. The human cells interacted with follicle epithelium to regenerate new end bulbs and create multiple differentiated hair fibers. Rodent tooth dental cells also induced new epithelial matrix structures and stimulated de novo hair formation. However, in many instances they also elicited mineralization and bone formation, a phenomenon that appeared to relate to their donor's age; the type of tooth of origin; and the host environment. Taken together, this study reveals that cultured dental papilla cells from postnatal mammals (adult, juvenile, and newborn) retain inductive molecular signals that must be common to both hair and teeth follicles. It highlights the stem cell-like qualities and morphogenetic abilities of tooth and hair follicle cells from mature humans, and their capacity for cross-appendage and interspecies communication and interaction. Besides the developmental implications, the present findings have relevance for stem cell biology, hair growth, tissue repair, and other biotechnologies. Moreover, the critical importance of considering the local microenvironment in which different cells/tissues are naturally or experimentally engineered is firmly demonstrated.
Authors:
Amanda J Reynolds; Colin A B Jahoda
Related Documents :
2995297 - Reversible contraction of isolated mammalian cochlear hair cells.
8310167 - Distortion product otoacoustic emissions in normally hearing subjects.
7270117 - Stereociliary dysfunction, a case of sensory hearing loss, recruitment, poor speech dis...
6125257 - Expression of gamma-glutamyl transpeptidase activity in the developing mouse tooth, int...
24700857 - Construction of a vertebrate embryo from two opposing morphogen gradients.
12456017 - Nad+ catabolism in pheochromocytoma rat cells.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Differentiation; research in biological diversity     Volume:  72     ISSN:  0301-4681     ISO Abbreviation:  Differentiation     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2004-12-24     Completed Date:  2005-05-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0401650     Medline TA:  Differentiation     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  566-75     Citation Subset:  IM    
Affiliation:
School of Biological and Biomedical Sciences, University of Durham, Durham, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Animals
Animals, Newborn
Cell Transplantation
Cells, Cultured
Dental Papilla / cytology*,  physiology,  transplantation*
Female
Fibroblasts / physiology
Hair / growth & development*
Hair Follicle / cytology,  physiology*
Humans
Male
Mice
Mice, Nude
Microdissection
Morphogenesis
Rats
Rats, Inbred Strains
Regeneration / physiology*
Stem Cells / cytology,  physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Transformation of amnion epithelium into skin and hair follicles.
Next Document:  Diet and physical activity behavior among users of prescription weight loss medications.