Document Detail


Cultured epidermal autografts: a life-saving and skin-saving technique in children.
MedLine Citation:
PMID:  1403529     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The recent more widespread availability of cultured keratinocytes has increased their clinical applicability in pediatric surgical problems. In life threatening burns (3 patients) and in elective procedures (3 patients) we have used sheets of cultured epithelial autografts. Body surface area affected ranged from fifteen to 85%. Five patients were successfully treated in one grafting session and one required four sessions. Take of the cultured keratinocytes ranged from 75% to 95%. Follow-up as long as 30 months has shown the skin to be comparable to if not superior to conventional split thickness grafts. The use of cultured keratinocytes allows wound coverage without expansion of the affected body surface area seen with conventional split-thickness skin grafting. Although there is an initial delay in the preparation of the grafts, the overall results have been excellent and suggest the more frequent use of this method.
Authors:
J J Coleman; B K Siwy
Related Documents :
6952249 - Selective proliferation of normal human melanocytes in vitro in the presence of phorbol...
21988089 - Design and validation of a compressive tissue stimulator with high-throughput capacity ...
8145539 - Basic fibroblast growth factor in the early human burn wound.
17274719 - Effect of in vitro gingival fibroblast seeding on the in vivo incorporation of acellula...
3428389 - Release of neuronotrophic factor from rabbit corneal epithelium during wound healing an...
15482829 - Formation of melanocyte spheroids on the chitosan-coated surface.
23447369 - A quantitative approach for understanding small-scale human mesenchymal stem cell cultu...
1999729 - Na(+)-current expression in rat hippocampal astrocytes in vitro: alterations during dev...
12692899 - Oxidative stress in cultured cerebral endothelial cells induces chromosomal aberrations...
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of pediatric surgery     Volume:  27     ISSN:  0022-3468     ISO Abbreviation:  J. Pediatr. Surg.     Publication Date:  1992 Aug 
Date Detail:
Created Date:  1992-11-18     Completed Date:  1992-11-18     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0052631     Medline TA:  J Pediatr Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1029-32     Citation Subset:  IM    
Affiliation:
Department of Surgery, Indiana University Medical Center, Indianapolis.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Burns / surgery*
Cells, Cultured
Child, Preschool
Epidermis / cytology*
Female
Humans
Infant
Male
Nevus, Pigmented / surgery*
Skin Neoplasms / surgery*
Skin Transplantation / methods*
Transplantation, Autologous / methods

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Growth hormone reverses impaired wound healing in protein-malnourished rats treated with corticoster...
Next Document:  Early induction of IL-6 in infants undergoing major abdominal surgery.