Document Detail


Cultured Kaposi's sarcoma tumor cells fail to stimulate T cell proliferation.
MedLine Citation:
PMID:  8625559     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Prior to the AIDS epidemic, Kaposi's sarcoma (KS) was a rare neoplasm. However, in the context of immunosuppression, cutaneous KS lesions more frequently develop and express various surface molecules recognized by T cells such as intercellular adhesion molecule-1 (ICAM-1; CD54) and HLA-DR. The KS tumor cells are thought to arise locally from endothelial cells via a transdifferentiation process. To determine if KS tumor cells can stimulate resting T cell proliferation, we asked whether the tumor cells express the critically important T cell costimulatory molecules B7-1 (CD-80) and B7-2 (CD-86). In contrast to cytokine-activated endothelial cells, which were induced to express B7-1, but not B7-2 and could function in bacteria-derived superantigen-driven T cell proliferation, four different KS tumor cell lines failed to express either B7-1 or B7-2 and were unable to stimulate allogeneic T cell proliferation upon addition of bacteria-derived superantigen. These results suggest that KS tumor cells behave differently in their response to cytokines compared with endothelial cells and may be able to evade the local immune response by not expressing costimulatory molecules necessary for T cell proliferation.
Authors:
K E Foreman; D Trinh; F O Nestle; R S Mitra; B J Nickoloff
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Clinical immunology and immunopathology     Volume:  78     ISSN:  0090-1229     ISO Abbreviation:  Clin. Immunol. Immunopathol.     Publication Date:  1996 Feb 
Date Detail:
Created Date:  1996-06-27     Completed Date:  1996-06-27     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0356637     Medline TA:  Clin Immunol Immunopathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  172-9     Citation Subset:  IM; X    
Affiliation:
Department of Pathology, University of Michigan, Ann Arbor 48109-0602, USA.
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MeSH Terms
Descriptor/Qualifier:
Antigens, Bacterial / immunology
Antigens, CD / analysis
Antigens, CD80 / analysis
Antigens, CD86
Endothelium, Vascular / immunology,  metabolism
Humans
Lymphocyte Activation*
Membrane Glycoproteins / analysis
Sarcoma, Kaposi / immunology*,  metabolism
Skin Neoplasms / immunology
Staphylococcus aureus / immunology
Superantigens / immunology
T-Lymphocytes / immunology*
Tumor Cells, Cultured
Grant Support
ID/Acronym/Agency:
AR40488/AR/NIAMS NIH HHS; CA63928/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Antigens, Bacterial; 0/Antigens, CD; 0/Antigens, CD80; 0/Antigens, CD86; 0/CD86 protein, human; 0/Membrane Glycoproteins; 0/Superantigens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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