Document Detail

Culture-confirmed typhoid fever and pregnancy.
MedLine Citation:
PMID:  17321180     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The relationship between pregnancy and typhoid fever is not well defined. The objective of this study was twofold: to assess the effect of the pregnant and postpartum host on typhoid disease expression, and to explore the relationship between typhoid fever and pregnancy outcome. METHODS: Over an 11-year period, all 181 adult women with blood culture-confirmed typhoid fever admitted to a university hospital in Karachi, Pakistan were studied; those with pregnancy-related disease were compared to the non-pregnant women. The relationship between typhoid fever and pregnancy outcome was evaluated by comparing 80 pregnant women with typhoid, with 194 randomly selected pregnant women without typhoid who were matched for age and study year. RESULTS: In adult females with bacteremic typhoid disease, a significant proportion was pregnancy-related (47%). These women were less likely to have other co-morbid illnesses (2% vs. 27%, p<0.001) and were almost exclusively treated with ampicillin/amoxicillin or third-generation cephalosporins, while the non-pregnant women with typhoid fever preferentially received quinolones. The mean duration of antimicrobial therapy was similar in both groups (14 days) but the non-pregnant group defervesced earlier (4.2 days vs. 5.6 days, p=0.011). Complications of typhoid fever were significantly more likely in the non-pregnant group (23% vs. 8%, p=0.005) and primarily involved lower gastrointestinal bleeding. On comparing the pregnant women with typhoid with randomly selected age-matched pregnant women without typhoid, there were no apparent effects of typhoid fever on pregnancy outcome as measured by gestational age at delivery, pregnancy complications, modes of delivery, neonate gender, birth weight, or birth Apgar scores. CONCLUSIONS: While pregnancy is a risk factor for and effects typhoid disease expression, typhoid fever does not appear to affect pregnancy outcome.
K Sulaiman; A R Sarwari
Publication Detail:
Type:  Journal Article     Date:  2007-02-23
Journal Detail:
Title:  International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases     Volume:  11     ISSN:  1201-9712     ISO Abbreviation:  Int. J. Infect. Dis.     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-07-03     Completed Date:  2007-11-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9610933     Medline TA:  Int J Infect Dis     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  337-41     Citation Subset:  IM    
Department of Medicine, Aga Khan University, Karachi, Pakistan.
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MeSH Terms
Pakistan / epidemiology
Pregnancy Complications, Infectious / drug therapy,  epidemiology,  microbiology*
Pregnancy Outcome
Retrospective Studies
Salmonella typhi / isolation & purification*
Typhoid Fever / complications*,  drug therapy,  epidemiology,  microbiology

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