Document Detail


Cultivation practices and manufacturing processes to produce Hoodia gordonii extract for weight management products.
MedLine Citation:
PMID:  22410259     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Hoodia gordonii (Masson) Sweet ex Decne., is a succulent shrub, indigenous to the arid regions of southern Africa. Indigenous people have historically utilised certain species of Hoodia, including H. gordonii, as a source of food and water. Studies by the Council for Scientific and Industrial Research (CSIR, South Africa) identified that extracts of H. gordonii had appetite suppressant activity associated with specific steroid glycosides. A programme to develop weight management products based around this discovery was implemented in 1998. An agronomy programme was established which demonstrated that it was possible to cultivate this novel crop on a commercial scale (in excess of 70ha). In parallel, a food grade manufacturing process was developed consisting of four main steps: harvesting of H. gordonii plant stems, comminution, drying under controlled conditions and extraction using food grade solvents. Appropriate Quality Control (QC) procedures were developed. The extraction process is capable of delivering a consistent composition despite natural variations in the composition of the dried H. gordonii. Specifications were developed for the resulting extract. The intended use of the standardised H. gordonii extract was as a functional food ingredient for weight management products. Other development studies on characterisation, toxicology and pharmacology are reported separately.
Authors:
Tamsin L Knight; Chris M Swindells; Andrew M Craddock; Vinesh J Maharaj; Sybille Buchwald-Werner; Smail Alaoui Ismaili; Simon C McWilliam
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association     Volume:  50 Suppl 1     ISSN:  1873-6351     ISO Abbreviation:  Food Chem. Toxicol.     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-03-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8207483     Medline TA:  Food Chem Toxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  S1-5     Citation Subset:  IM    
Copyright Information:
Copyright © 2011. Published by Elsevier Ltd.
Affiliation:
Phytopharm plc, Lakeview House, 2 Lakeview Court, Ermine Business Park, Huntingdon, Cambridgeshire, PE29 6UA, UK.
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