| Cultivation of epithelial-associated microbiota by the immune system. | |
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MedLine Citation:
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PMID: 21073309 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Mounting evidence supports the intuitive idea that many of the factors produced in defense of the epithelial surface, including mucin and secretory IgA, promote the growth of the commensal microbial flora, much the same as plant-derived mucoid substances support the growth of symbiotic microbes in the rhizosphere associated with roots. Thus, the 'defense' of the host epithelial surface often involves support and maintenance of microbial growth, despite an unfortunate tendency to view the immune system as an antagonist to the microbial flora. The perspective that the immune system supports the growth of a symbiotic microbiota has the potential to push forward our understanding of host-microbe interactions and to facilitate the development of new treatments for diseases associated with the microbiota. |
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Authors:
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Anitra D Thomas; William Parker |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Future microbiology Volume: 5 ISSN: 1746-0921 ISO Abbreviation: Future Microbiol Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-11-15 Completed Date: 2011-02-25 Revised Date: 2011-04-11 |
Medline Journal Info:
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Nlm Unique ID: 101278120 Medline TA: Future Microbiol Country: England |
Other Details:
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Languages: eng Pagination: 1483-92 Citation Subset: IM |
Affiliation:
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Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Epithelium / microbiology* Humans Immune System / microbiology* Metagenome / immunology*, physiology* Symbiosis* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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