Document Detail

Cuf2 boosts the transcription of APC/C activator Fzr1 to terminate the meiotic division cycle.
MedLine Citation:
PMID:  23628763     Owner:  NLM     Status:  MEDLINE    
The number of nuclear divisions in meiosis is strictly limited to two. Although the precise mechanism remains unknown, this seems to be achieved by adjusting the anaphase-promoting complex/cyclosome (APC/C) activity to degrade cyclin. Here, we describe a fission yeast cuf2 mutant that enters into a third nuclear division cycle, represented by ectopic spindle assembly and abnormal chromosome segregation. Cuf2 is a meiotic transcription factor, and its critical target is fzr1(+)/mfr1(+), which encodes a meiotic APC/C activator. fzr1Δ also enters a third nuclear division. Thus, Cuf2 ensures termination of the M-phase cycle by boosting Fzr1 expression to generate functional gametes.
Yuki Aoi; Kunio Arai; Masaya Miyamoto; Yuji Katsuta; Akira Yamashita; Masamitsu Sato; Masayuki Yamamoto
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-04-30
Journal Detail:
Title:  EMBO reports     Volume:  14     ISSN:  1469-3178     ISO Abbreviation:  EMBO Rep.     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-06-03     Completed Date:  2013-10-18     Revised Date:  2014-06-03    
Medline Journal Info:
Nlm Unique ID:  100963049     Medline TA:  EMBO Rep     Country:  England    
Other Details:
Languages:  eng     Pagination:  553-60     Citation Subset:  IM    
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MeSH Terms
Cdh1 Proteins
Cell Cycle Proteins / genetics*,  metabolism,  physiology*
Cyclin B / metabolism
Gene Expression Regulation, Fungal*
Gene Knockout Techniques
Schizosaccharomyces / cytology,  physiology*
Schizosaccharomyces pombe Proteins / genetics*,  metabolism,  physiology*
Single-Cell Analysis
Spores, Fungal / cytology,  physiology
Transcription, Genetic
Reg. No./Substance:
0/Cdc13 protein, S pombe; 0/Cdh1 Proteins; 0/Cell Cycle Proteins; 0/Cuf2 protein, S pombe; 0/Cyclin B; 0/Mes1 protein, S pombe; 0/Schizosaccharomyces pombe Proteins; 0/mfr1 protein, S pombe

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