Document Detail

Cue-reactors: individual differences in cue-induced craving after food or smoking abstinence.
MedLine Citation:
PMID:  21085667     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Pavlovian conditioning plays a critical role in both drug addiction and binge eating. Recent animal research suggests that certain individuals are highly sensitive to conditioned cues, whether they signal food or drugs. Are certain humans also more reactive to both food and drug cues?
METHODS: We examined cue-induced craving for both cigarettes and food, in the same individuals (n = 15 adult smokers). Subjects viewed smoking-related or food-related images after abstaining from either smoking or eating.
RESULTS: Certain individuals reported strong cue-induced craving after both smoking and food cues. That is, subjects who reported strong cue-induced craving for cigarettes also rated stronger cue-induced food craving.
CONCLUSIONS: In humans, like in nonhumans, there may be a "cue-reactive" phenotype, consisting of individuals who are highly sensitive to conditioned stimuli. This finding extends recent reports from nonhuman studies. Further understanding this subgroup of smokers may allow clinicians to individually tailor therapies for smoking cessation.
Stephen V Mahler; Harriet de Wit
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, N.I.H., Extramural     Date:  2010-11-10
Journal Detail:
Title:  PloS one     Volume:  5     ISSN:  1932-6203     ISO Abbreviation:  PLoS ONE     Publication Date:  2010  
Date Detail:
Created Date:  2010-11-18     Completed Date:  2011-04-27     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  101285081     Medline TA:  PLoS One     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e15475     Citation Subset:  IM    
Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina, United States of America.
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MeSH Terms
Conditioning (Psychology)
Eating / psychology
Smoking / psychology*
Smoking Cessation / psychology*
Young Adult
Grant Support

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