Document Detail

Cue-induced reinstatement of ethanol seeking in Sardinian alcohol-preferring rats.
MedLine Citation:
PMID:  17452297     Owner:  NLM     Status:  MEDLINE    
The purpose of the present study was to characterize cue-induced reinstatement of ethanol seeking in selectively bred Sardinian alcohol-preferring (sP) rats trained to lever press for ethanol in 30-min self-administration sessions. Four responses on an "active" lever led to presentation of 0.1 ml of 15% (vol/vol) ethanol by a liquid dipper and concurrent activation of a set of discrete light and auditory cues. In a 70-min extinction/reinstatement session, responding was first extinguished for 60 min. Subsequently, different stimuli were delivered in a noncontingent manner and reinstatement of nonreinforced responding was assessed. Fifteen presentations of the ethanol-predictive stimulus complex, including the dipper cup containing 5 or 15% ethanol, potently reinstated responding on the previously active lever. The magnitude of reinstatement increased with the number of stimulus presentations and concentration of ethanol presented by the dipper cup. Fifteen presentations of the ethanol-predictive stimulus complex, including the dipper cup filled with water (0% ethanol), did not produce any reinstatement. These results indicate that (1) noncontingent presentations of the ethanol-predictive stimulus complex may reinstate ethanol seeking in sP rats and (2) the orosensory properties of ethanol may play an important role in reinstatement of ethanol seeking in sP rats. The latter finding concurs with clinical observations that odor and taste of alcoholic beverages elicit immediate craving responses in abstinent alcoholics.
Paola Maccioni; Alessandro Orrú; Agnieszka Korkosz; Gian Luigi Gessa; Mauro A M Carai; Giancarlo Colombo; Przemyslaw Bienkowski
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Alcohol (Fayetteville, N.Y.)     Volume:  41     ISSN:  0741-8329     ISO Abbreviation:  Alcohol     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-04-24     Completed Date:  2007-06-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8502311     Medline TA:  Alcohol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  31-9     Citation Subset:  IM    
C.N.R. Institute of Neuroscience, Viale Diaz 182, I-09126, Cagliari, Italy.
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MeSH Terms
Acoustic Stimulation
Alcohol Drinking / physiopathology,  psychology*
Alcoholism / physiopathology,  psychology
Behavior, Animal*
Central Nervous System Depressants / administration & dosage*,  blood
Conditioning, Operant
Ethanol / administration & dosage*,  blood
Extinction, Psychological
Photic Stimulation
Rats, Inbred Strains
Reinforcement Schedule
Self Administration
Substance Withdrawal Syndrome / physiopathology,  psychology
Reg. No./Substance:
0/Central Nervous System Depressants; 64-17-5/Ethanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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