| Cue-induced craving and physiological reactions in recently and long-abstinent heroin-dependent patients. | |
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MedLine Citation:
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PMID: 22177521 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To understand the different patterns of cue-induced craving and physiological reactions among recently abstinent and long-abstinent heroin-dependent patients. METHOD: 26 healthy adult controls (HC), 29 long-abstinent (more than 1 year, LA), and 26 recently abstinent (less than 1 month, RA) heroin-dependent individuals were exposed to heroin-related and neutral video cues, one video per session, on different days in random order. Self-reported heroin craving by a 10-point visual analog scale (VAS), physiological reactions [skin conductance (SC), muscle electromyography (MEG), skin temperature (TEMP)] and cardiovascular arousal [heart rates (HR), systolic blood pressure (HBP) and diastolic blood pressure (LBP)] were assessed at baseline and after exposure. RESULTS: Both heroin-abstinent groups showed increased heroin craving, SC, MEG, HR, SBP and LBP after exposure to heroin-related video, compared to the control group and compared to exposure to the neutral video. Except the RA group showed more HR changes, changes of heroin craving, SC, MEG, HR, SBP and LBP after exposure to the heroin cue video were not different between the LA and RA groups. CONCLUSIONS: Abstinent heroin-dependent patients had elevated craving and physiological reactions after exposure to videos containing heroin-related cues and the cue induced responses still occurred in long-abstinent patients. This phenomenon should be addressed in treatment and recovery services for heroin dependence. |
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Authors:
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Min Zhao; Chenglu Fan; Jiang Du; Haifeng Jiang; Hanhui Chen; Haiming Sun |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. Date: 2011-11-29 |
Journal Detail:
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Title: Addictive behaviors Volume: 37 ISSN: 1873-6327 ISO Abbreviation: Addict Behav Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-02-20 Completed Date: 2012-05-09 Revised Date: 2013-04-03 |
Medline Journal Info:
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Nlm Unique ID: 7603486 Medline TA: Addict Behav Country: England |
Other Details:
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Languages: eng Pagination: 393-8 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Ltd. All rights reserved. |
Affiliation:
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Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 600 Wan Ping Nan Road, Shanghai 200030, China. drzhaomin@gmail.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Analysis of Variance Blood Pressure / physiology Body Temperature / physiology Case-Control Studies Cues* Electromyography Female Galvanic Skin Response / physiology Heart Rate / physiology Heroin Dependence / physiopathology, psychology* Humans Male Motivation* Muscle, Skeletal / physiology Videotape Recording |
| Grant Support | |
ID/Acronym/Agency:
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R01 TW007279-01A1/TW/FIC NIH HHS; R01TW007279/TW/FIC NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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