| Cucurbitane-type triterpenes with anti-proliferative effects on U937 cells from an egyptian natural medicine, Bryonia cretica: structures of new triterpene glycosides, bryoniaosides A and B. | |
MedLine Citation:
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PMID: 20460809 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The 90% aqueous ethanol extract of an Egyptian natural medicine, the roots of Bryonia cretica L., was found to exhibit a strong inhibitory effect on the proliferation of human leukemia U937 cells. By bioassay-guided fractionation, we isolated two new cucurbitane-type triterpene glycosides, bryoniaosides A and B, were isolated from the roots of Bryonia cretica L. together with 16 known cucurbitane-type triterpenes and glycosides. The chemical structures of bryoniaosides A and B were determined on the basis of chemical and spectroscopic evidence. Effects of principal cucurbitane-type triterpenes (cucurbitacins B, D, E, and J, 23,24-dihydrocucurbitacins B and E, and hexanorcucurbitacin D) on proliferation of the cells were examined. Cucurbitacins B and E showed the greater cytotoxic effects with IC(50) values of 9.2 and 16 nM after 72 h, and their IC(50) values were equivalent to that of camptothecin. An alpha,beta-conjugated ketone moiety at the 22-24-positions and an acetoxy group at the 25-position are essential for the strong activity. |
Authors:
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Hisashi Matsuda; Souichi Nakashima; Osama Bashir Abdel-Halim; Toshio Morikawa; Masayuki Yoshikawa |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Chemical & pharmaceutical bulletin Volume: 58 ISSN: 1347-5223 ISO Abbreviation: Chem. Pharm. Bull. Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-05-12 Completed Date: 2010-09-01 Revised Date: 2011-03-08 |
Medline Journal Info:
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Nlm Unique ID: 0377775 Medline TA: Chem Pharm Bull (Tokyo) Country: Japan |
Other Details:
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Languages: eng Pagination: 747-51 Citation Subset: IM |
Affiliation:
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Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto 607-8412, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antineoplastic Agents, Phytogenic
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pharmacology* Bryonia / chemistry* Cell Proliferation / drug effects Egypt Glycosides / chemistry*, isolation & purification, pharmacology Humans Inhibitory Concentration 50 Leukemia / drug therapy Magnetic Resonance Spectroscopy Molecular Structure Plant Extracts / chemistry*, pharmacology Plant Roots / chemistry* Triterpenes / chemistry*, isolation & purification, pharmacology U937 Cells |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents, Phytogenic; 0/Glycosides; 0/Plant Extracts; 0/Triterpenes; 0/bryoniaoside A; 0/bryoniaoside B; 0/cucurbitane |
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