| Cucurbitane-type triterpenes with anti-proliferative effects on U937 cells from an egyptian natural medicine, Bryonia cretica: structures of new triterpene glycosides, bryoniaosides A and B. | |
MedLine Citation:
|
PMID: 20460809 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The 90% aqueous ethanol extract of an Egyptian natural medicine, the roots of Bryonia cretica L., was found to exhibit a strong inhibitory effect on the proliferation of human leukemia U937 cells. By bioassay-guided fractionation, we isolated two new cucurbitane-type triterpene glycosides, bryoniaosides A and B, were isolated from the roots of Bryonia cretica L. together with 16 known cucurbitane-type triterpenes and glycosides. The chemical structures of bryoniaosides A and B were determined on the basis of chemical and spectroscopic evidence. Effects of principal cucurbitane-type triterpenes (cucurbitacins B, D, E, and J, 23,24-dihydrocucurbitacins B and E, and hexanorcucurbitacin D) on proliferation of the cells were examined. Cucurbitacins B and E showed the greater cytotoxic effects with IC(50) values of 9.2 and 16 nM after 72 h, and their IC(50) values were equivalent to that of camptothecin. An alpha,beta-conjugated ketone moiety at the 22-24-positions and an acetoxy group at the 25-position are essential for the strong activity. |
Authors:
|
Hisashi Matsuda; Souichi Nakashima; Osama Bashir Abdel-Halim; Toshio Morikawa; Masayuki Yoshikawa |
Related Documents
:
|
22757199 - We-c-bra-09: towards treatment monitoring of tumour radiation response with raman spect... 11428649 - Sulfur mustard induces apoptosis and necrosis in scl ii cells in vitro. 21497989 - Cooperation of the hdac inhibitor vorinostat and radiation in metastatic neuroblastoma:... 17904839 - Synthesis and biological evaluation of novel cytotoxic azanaphthoquinone annelated pyrr... 16824549 - Selective cytotoxicity of withaphysalins in myeloid leukemia cell lines versus peripher... 1538139 - A colorimetric microtiter assay for the quantitation of cytokine activity on adherent c... 23342249 - Overexpression of snail induces epithelial-mesenchymal transition and a cancer stem cel... 19965369 - Micrornas couple cell fate and developmental timing in retina. 12124469 - Adenovirus e1-transformed cells grow despite the continuous presence of transcriptional... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Chemical & pharmaceutical bulletin Volume: 58 ISSN: 1347-5223 ISO Abbreviation: Chem. Pharm. Bull. Publication Date: 2010 May |
Date Detail:
|
Created Date: 2010-05-12 Completed Date: 2010-09-01 Revised Date: 2011-03-08 |
Medline Journal Info:
|
Nlm Unique ID: 0377775 Medline TA: Chem Pharm Bull (Tokyo) Country: Japan |
Other Details:
|
Languages: eng Pagination: 747-51 Citation Subset: IM |
Affiliation:
|
Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto 607-8412, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Antineoplastic Agents, Phytogenic
/
pharmacology* Bryonia / chemistry* Cell Proliferation / drug effects Egypt Glycosides / chemistry*, isolation & purification, pharmacology Humans Inhibitory Concentration 50 Leukemia / drug therapy Magnetic Resonance Spectroscopy Molecular Structure Plant Extracts / chemistry*, pharmacology Plant Roots / chemistry* Triterpenes / chemistry*, isolation & purification, pharmacology U937 Cells |
| Chemical | |
Reg. No./Substance:
|
0/Antineoplastic Agents, Phytogenic; 0/Glycosides; 0/Plant Extracts; 0/Triterpenes; 0/bryoniaoside A; 0/bryoniaoside B; 0/cucurbitane |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: New phenylpropanoid glycosides from Juniperus communis var. depressa.
Next Document: Rational design and synthesis of 4-o-substituted phenylmethylenethiosemicarbazones as novel tyrosina...