Document Detail


Cu2+ -induced low density lipoprotein peroxidation is dependent on the initial O2 concentration: an O2 consumption study.
MedLine Citation:
PMID:  11104014     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Atherosclerotic plaques form in the arterial intima, where low density lipoprotein (LDL) is thought to be oxidatively modified at sites which may contain catalytic amounts of copper in the presence of low O2 tension. We have investigated O2 consumption during LDL peroxidation induced by Cu2+ ions in vitro and found two phases: a lag phase followed by a phase of rapid O2 consumption. The length of the lag phase was dependent on Cu2+ and on initial O2 concentrations; increasing either decreased the lag time; however, LDL. concentration had no effect. LDL-induced Cu2+ reduction, however, was not affected by low initial O2 concentrations, suggesting that O2 is not required for LDL-mediated reduction of Cu2+. Following the lag phase, O2 consumption was dependent upon LDL or initial O2 concentrations; Cu2+ concentrations had little effect, suggesting that the propagation phase is more dependent on the presence of LDL lipids and O2 as substrates for the reaction. In summary, LDL peroxidation takes place in the presence of Cu2+ at low O2 tension; however, the reaction is dependent upon initial O2 concentrations; increases shorten the lag phase and accelerate O2 consumption.
Authors:
J K Lodge; M G Traber; P J Sadler
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Lipids     Volume:  35     ISSN:  0024-4201     ISO Abbreviation:  Lipids     Publication Date:  2000 Oct 
Date Detail:
Created Date:  2001-02-05     Completed Date:  2001-03-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0060450     Medline TA:  Lipids     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1087-92     Citation Subset:  IM    
Affiliation:
Department of Chemistry, Birkbeck College, University of London, United Kingdom. j.lodge@surrey.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Copper / pharmacology*
Dose-Response Relationship, Drug
Humans
Kinetics
Lipid Peroxidation
Lipoproteins, LDL / blood,  metabolism*
Oxidation-Reduction
Oxygen / metabolism*
Oxygen Consumption*
Peroxides / metabolism*
Spectrophotometry
Time Factors
Ultraviolet Rays
Chemical
Reg. No./Substance:
0/Lipoproteins, LDL; 0/Peroxides; 7440-50-8/Copper; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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