Document Detail

Cu to Zn ratio, physical function, disability, and mortality risk in older elderly (ilSIRENTE study).
MedLine Citation:
PMID:  21544579     Owner:  NLM     Status:  MEDLINE    
Associations between copper to zinc ratio (CZr) and mortality have suggested CZr as a biomarker of aging. Nevertheless, very limited data exist on the association between serum CZr and physical or functional status of very old people. We examined the relationship between serum CZr and physical performance, muscle strength, functional status, and survival from the ilSIRENTE Study: a longitudinal study of persons aged 80 years or older (n = 346). An adjusted linear regression model was subsequently performed to calculate the regression coefficients of the associations between baseline physical and functional measures (dependent variable) with CZr or "Cu and Zn" alone taking also into account the influence of other relevant factors, including hematological (albumin, cholesterol, and urea) and inflammatory biomarkers (IL-6 and CRP) that were significantly different across CZr tertiles. CZr showed significant and stronger relationships than Cu or Zn alone with all baseline physical and functional measures in models that did not include adjustments for inflammatory parameters. CZr was also associated with physical decline, measured as "SPPB% decline" at 2 years of follow-up and mortality at 4 years of follow-up. Subjects in the high CZr tertile had a higher risk of death with an adjusted hazard ratio of 1.92 (95% CI, 1.12-3.29; p = 0.02). In conclusion, we have confirmed the role of CZr as a predictor of mortality, whereas the role of CZr as a biomarker or predictor of physical or functional performance seems to be the consequence of its strict relationships with inflammatory parameters. In this context, further investigations need to be carried out.
Eugenio Mocchegiani; Marco Malavolta; Fabrizia Lattanzio; Francesco Piacenza; Andrea Basso; Angela Marie Abbatecola; Andrea Russo; Silvia Giovannini; Ettore Capoluongo; Silvia Bustacchini; Enrico Eugenio Guffanti; Roberto Bernabei; Francesco Landi
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-05-05
Journal Detail:
Title:  Age (Dordrecht, Netherlands)     Volume:  34     ISSN:  1574-4647     ISO Abbreviation:  Age (Dordr)     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-04-27     Completed Date:  2012-09-25     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  101250497     Medline TA:  Age (Dordr)     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  539-52     Citation Subset:  IM    
Centre of Nutrition and Ageing, Scientific and Technological Area, INRCA, Ancona, Italy.
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MeSH Terms
Activities of Daily Living*
Aged, 80 and over
Aging / physiology*
Biological Markers / blood
Cause of Death / trends
Copper / blood*
Disabled Persons*
Follow-Up Studies
Frail Elderly / statistics & numerical data
Italy / epidemiology
Motor Activity / physiology*
Muscle Strength
Nutritional Status*
Prospective Studies
Risk Factors
Survival Rate / trends
Zinc / blood*
Reg. No./Substance:
0/Biological Markers; 7440-50-8/Copper; 7440-66-6/Zinc

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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