Document Detail


Cu-ATSM, an intracellular-accessible superoxide dismutase (SOD)-like copper complex: evaluation in an ischemia-reperfusion injury model.
MedLine Citation:
PMID:  7920437     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have reported a stable superoxide dismutase (SOD)-like copper complex, Cu-ATSM, which shows high membrane permeability and distribution to the brain or heart. In this study, we evaluated the protective effects of Cu-ATSM on superoxide-mediated tissue damage caused by ischemia-reperfusion using an isolated perfused rat heart model. Lipid peroxidation levels in the Cu-ATSM treated group were lower than those in the non-treated group. Furthermore, released creatine phosphokinase into the perfusate, a marker of tissue damage, was reduced by Cu-ATSM treatment. These results indicated the possibility of Cu-ATSM being an effective SOD-like drug for the treatment of superoxide-mediated damage, such as ischemia-reperfusion injury.
Authors:
K Wada; Y Fujibayashi; N Tajima; A Yokoyama
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Biological & pharmaceutical bulletin     Volume:  17     ISSN:  0918-6158     ISO Abbreviation:  Biol. Pharm. Bull.     Publication Date:  1994 May 
Date Detail:
Created Date:  1994-10-25     Completed Date:  1994-10-25     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9311984     Medline TA:  Biol Pharm Bull     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  701-4     Citation Subset:  IM    
Affiliation:
Department of Radiopharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Kyoto University, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Coronary Circulation / drug effects
Creatine Kinase / metabolism
Free Radical Scavengers*
Hemodynamics / drug effects
Male
Myocardial Ischemia / drug therapy,  physiopathology*
Myocardial Reperfusion Injury / drug therapy,  physiopathology*
Myocardium / enzymology
Organometallic Compounds / pharmacology*
Rats
Rats, Wistar
Superoxide Dismutase / pharmacology*
Superoxides / toxicity
Thiobarbituric Acid Reactive Substances / metabolism
Thiosemicarbazones / pharmacology*
Chemical
Reg. No./Substance:
0/Free Radical Scavengers; 0/Organometallic Compounds; 0/Thiobarbituric Acid Reactive Substances; 0/Thiosemicarbazones; 0/copper (II) diacetyl-di(N(4)-methylthiosemicarbazone); 11062-77-4/Superoxides; EC 1.15.1.1/Superoxide Dismutase; EC 2.7.3.2/Creatine Kinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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