Document Detail


Cthrc1 is a negative regulator of myelination in Schwann cells.
MedLine Citation:
PMID:  22379615     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
The analysis of the molecular mechanisms involved in the initial interaction between neurons and Schwann cells is a key issue in understanding the myelination process. We recently identified Cthrc1 (Collagen triple helix repeat containing 1) as a gene upregulated in Schwann cells upon interaction with the axon. Cthrc1 encodes a secreted protein previously shown to be involved in migration and proliferation in different cell types. We performed a functional analysis of Cthrc1 in Schwann cells by loss-of- and gain-of-function approaches using RNA interference knockdown in cell culture and a transgenic mouse line that overexpresses the gene. This work establishes that Cthrc1 enhances Schwann cell proliferation but prevents myelination. In particular, time-course analysis of myelin formation intransgenic animals reveals that overexpression of Cthrc1 in Schwann cells leads to a delay in myelin formation with cells maintaining a proliferative state. Our data, therefore, demonstrate that Cthrc1 plays a negative regulatory role, fine-tuning the onset of peripheral myelination.
Authors:
Caroline Apra; Laurence Richard; Fanny Coulpier; Corinne Blugeon; Pascale Gilardi-Hebenstreit; Jean-michel Vallat; Volkhard Lindner; Patrick Charnay; Laurence Decker
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Glia     Volume:  60     ISSN:  1098-1136     ISO Abbreviation:  Glia     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-02-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8806785     Medline TA:  Glia     Country:  United States    
Other Details:
Languages:  eng     Pagination:  393-403     Citation Subset:  IM    
Affiliation:
Ecole Normale Supérieure, IBENS, Developmental Biology Section, 75230 Paris cedex 05, France.
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Descriptor/Qualifier:
Grant Support
ID/Acronym/Agency:
HL69182/HL/NHLBI NIH HHS; P20 RR-15555/RR/NCRR NIH HHS

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