Document Detail

Ctenus medius and Phoneutria nigriventer spiders venoms share noxious proinflammatory activities.
MedLine Citation:
PMID:  19198518     Owner:  NLM     Status:  MEDLINE    
Ctenus medius Keyserling, 1891 (Araneae: Ctenidae) co-occurs in various microhabitats of the Brazilian Atlantic Forest and can be easily misidentified as the medically important spider Phoneutria nigriventer Keyserling, 1981 (Ctenidae). Despite being phylogenetically close to Phoneutria, no data are available about the toxic potential of Ctenus medius venom. Here we show that, although presenting different profile of protein composition, C. medius venom displays some of the toxic properties exhibited by P. nigriventer venom, including proteolytic, hyaluronidasic and phospholipasic activities, as well as the ability of causing hyperalgesia and edema. Moreover, C. medius venom interferes in the activation of the complement system in concentrations that P. nigriventer venom is inactive. Thus, these data show that venoms of spiders from Ctenidae family share important proinflammatory properties and suggest that the C. medius bite may have an important noxious effect in human accidents.
Cinthya Kimori Okamoto; Rute M Gonçalves-De-Andrade; Giselle Pidde Queiroz; Vanessa P Gutierez; Daniel Manzoni De Almeida; Yara Cury; Rogério Bertani; Fernanda C V Portaro; Denise V Tambourgi
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of medical entomology     Volume:  46     ISSN:  0022-2585     ISO Abbreviation:  J. Med. Entomol.     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2009-02-09     Completed Date:  2009-03-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375400     Medline TA:  J Med Entomol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  58-66     Citation Subset:  IM    
Laboratório de Imunoquímica, Instituto Butantan, Av. Prof. Vital Brazil, 1500, CEP 05503-900, São Paulo, Brazil.
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MeSH Terms
Blotting, Western
Edema / chemically induced
Electrophoresis, Polyacrylamide Gel
Hyperalgesia / chemically induced
Rats, Wistar
Spider Venoms / enzymology,  toxicity*
Spiders / chemistry*
Reg. No./Substance:
0/Spider Venoms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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