Document Detail


Crystal structure of doisynolic acid and the structure of other products formed during its synthesis.
MedLine Citation:
PMID:  7792828     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The crystal structure of the D-seco-estrogen doisynolic acid shows it to have the natural S configuration at the position derived from C-14 in estrone. Two major by-products during the synthesis of doisynolic acid from estrone are shown to be dimeric steroids. One is an aldol condensation product, and the other appears to arise from an alkaline cleavage of the aldol product.
Authors:
D Y Chi; S R Wilson; J A Katzenellenbogen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Steroids     Volume:  60     ISSN:  0039-128X     ISO Abbreviation:  Steroids     Publication Date:  1995 Mar 
Date Detail:
Created Date:  1995-07-27     Completed Date:  1995-07-27     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0404536     Medline TA:  Steroids     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  261-4     Citation Subset:  IM    
Affiliation:
Department of Chemistry, University of Illinois, Urbana 61801, USA.
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MeSH Terms
Descriptor/Qualifier:
Crystallization
Crystallography, X-Ray
Estrenes / chemical synthesis,  chemistry*
Estrone / chemistry
Hydrogen-Ion Concentration
Hydroxides
Macromolecular Substances
Molecular Conformation
Molecular Structure
Potassium Compounds
Secosteroids / chemical synthesis,  chemistry*
Grant Support
ID/Acronym/Agency:
5R37 DK15556/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Estrenes; 0/Hydroxides; 0/Macromolecular Substances; 0/Potassium Compounds; 0/Secosteroids; 1310-58-3/potassium hydroxide; 482-49-5/doisynolic acid; 53-16-7/Estrone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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