Document Detail

Crystal-storing histiocytosis: report of a case, review of the literature (80 cases) and a proposed classification.
MedLine Citation:
PMID:  22430767     Owner:  NLM     Status:  MEDLINE    
We report a case of crystal storing histiocytosis (CSH) of the upper lip and cheek in a 51-year-old woman and review the clinicopathologic features of 80 cases in the literature. These occurred in 41 men and 39 women with a respective mean age of 59 and 61 years (range 17-81 years). Forty-six patients (58%) had localized CSH, and, of these, 16 (35%) occurred in the head and neck, with the most common site being the eye/orbit. The remaining 34 patients (42%) had generalized CSH primarily involving bone marrow, liver, lymph nodes, spleen and/or kidney. Regardless of whether the CSH was localized or generalized, the vast majority of patients (90%) had an underlying lymphoproliferative or plasma cell disorder, especially multiple myeloma, lymphoplasmacytic lymphoma, or monoclonal gammopathy of undetermined significance. In 7 cases (8.8%), the CSH was associated with a variety of benign disorders, often with an inflammatory background, and no evidence of a clonal lymphoproliferative or plasma cell disorder. Treatment and prognosis varied according to the underlying disease. A classification of CSH based on etiology and/or associated disease and chemical composition of the crystal is proposed, rare non-immunoglobulin variants of CSH are discussed, and a differential diagnosis of other potentially confusing lesions is provided.
Snjezana Dogan; Leon Barnes; Wilhelmina P Cruz-Vetrano
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Publication Detail:
Type:  Case Reports; Journal Article; Review     Date:  2012-03-20
Journal Detail:
Title:  Head and neck pathology     Volume:  6     ISSN:  1936-0568     ISO Abbreviation:  Head Neck Pathol     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-03-26     Completed Date:  2012-07-24     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  101304010     Medline TA:  Head Neck Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  111-20     Citation Subset:  IM    
Department of Pathology, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, New York, NY 10065, USA.
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MeSH Terms
Diagnosis, Differential
Histiocytes / chemistry,  pathology*,  ultrastructure
Histiocytosis / classification*,  pathology*
Immunoglobulins / analysis
Lip / pathology*
Microscopy, Electron
Middle Aged
Reg. No./Substance:

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