| Cryptorchidism concordance in monozygotic and dizygotic twin brothers, full brothers, and half-brothers. | |
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MedLine Citation:
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PMID: 19022430 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To study concordance rates of cryptorchidism (undescended testis) in pairs of boys with varying family structure, to evaluate the risk contribution from the intrauterine environment and genetic factors. DESIGN: Population based study of 1,024,500 Danish boys born from January 1, 1973 to December 31, 2004. Classic twin method and computerized square dance design. SETTING: Hospitals and outpatient clinics. PATIENT(S): Six groups of boy pairs: boys with no relation, paternal half-brothers, maternal half-brothers, full brothers, dizygotic twin brothers, and monozygotic twin brothers. INTERVENTION(S): Observational study. MAIN OUTCOME MEASURE(S): Status on each individual regarding cryptorchidism and orchiopexy from the Danish National Patient Register. RESULT(S): Concordance rates of cryptorchidism in the groups were as follows: boys with no relation 3.2% (95% confidence interval 2.7%-3.6%), paternal half-brothers 3.4% (2.3%-4.7%), maternal half-brothers 6.0% (4.5%-7.7%), full brothers 8.8% (8.3%-9.8%), dizygotic twin brothers 24.1% (16.0%-33.6%), and monozygotic twin brothers 27.3% (15.5%-41.2%). CONCLUSION(S): The concordance rate was higher in maternal than in paternal half-brothers, and much higher but of equal magnitude in both twin groups. The findings strongly support that the intrauterine environment and maternal inheritance are contributing to the occurrence of cryptorchidism. |
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Authors:
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Morten S?ndergaard Jensen; Gunnar Toft; Ane Marie Thulstrup; Tine Brink Henriksen; J?rn Olsen; Kaare Christensen; Jens Peter Bonde |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Twin Study Date: 2008-11-19 |
Journal Detail:
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Title: Fertility and sterility Volume: 93 ISSN: 1556-5653 ISO Abbreviation: Fertil. Steril. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-01-27 Completed Date: 2010-02-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: United States |
Other Details:
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Languages: eng Pagination: 124-9 Citation Subset: IM |
Copyright Information:
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Copyright 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Occupational Medicine, Aarhus University Hospital, Aarhus, Denmark. morten@sondergaard-jensen.dk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Child Child, Preschool Cryptorchidism / genetics*, surgery Denmark Environment Genetic Predisposition to Disease Heredity Humans Logistic Models Male Odds Ratio Orchiopexy Pedigree Registries Risk Assessment Risk Factors Twins, Dizygotic / genetics* Twins, Monozygotic / genetics* Young Adult |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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