Document Detail

Cryptomeria japonica essential oil inhibits the growth of drug-resistant skin pathogens and LPS-induced nitric oxide and pro-inflammatory cytokine production.
MedLine Citation:
PMID:  19469288     Owner:  NLM     Status:  MEDLINE    
In this study, the chemical composition of Cryptomeria japonica essential oil (CJE) was analyzed and its biological activities were tested. CJE was obtained by steam distillation from leaves collected from Jeju Island and analyzed by gas chromatography (GC)-flame ionization detection (FID) and GC-MS. Kaurene (17.20%), elemol (10.88%), gamma-eudesmol (9.41%), and sabinene (8.86%) were the major components in CJE. The antibacterial and anti-inflammatory activities of CJE against drug-susceptible and -resistant skin pathogens have been not reported previously. Thus, we determined the anti-bacterial activities of CJE using the disk diffusion method and minimum inhibitory concentration (MIC) values. CJE showed excellent antibacterial activities against Propionibacterium acnes and Staphylococcus epidermidis, which are acne-causing bacteria. The MIC of CJE against drug-susceptible and -resistant P. acens and S. epidermidis ranged from 0.16 to 10.0 microl/ml. In addition, the effects of CJE on nitric oxide (NO), prostaglandin E2 (PGE2), tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, and IL-6 production in lipopolysaccharide (LPS)-activated RAW 264.7 macrophages were also examined. Pro-inflammatory cytokine and mediator tests indicated that CJE has excellent dose-dependent inhibitory activities. Therefore, based on these results, we propose that CJE is an attractive acne-mitigating candidate for skin health.
Weon-Jong Yoon; Sang-Suk Kim; Tae-Heon Oh; Nam Ho Lee; Chang-Gu Hyun
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Polish journal of microbiology / Polskie Towarzystwo Mikrobiologów = The Polish Society of Microbiologists     Volume:  58     ISSN:  1733-1331     ISO Abbreviation:  Pol. J. Microbiol.     Publication Date:  2009  
Date Detail:
Created Date:  2009-05-27     Completed Date:  2009-06-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101229003     Medline TA:  Pol J Microbiol     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  61-8     Citation Subset:  IM    
Research Group for Cosmetic Materials, Jeju Biodiversity Research Institute, Jeju High-Tech Development Institute, Jeju, Korea.
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MeSH Terms
Acne Vulgaris / drug therapy*,  pathology
Cell Line
Cytokines / biosynthesis*
Drug Resistance, Bacterial
Gas Chromatography-Mass Spectrometry
Inflammation / drug therapy,  metabolism
Lipopolysaccharides / metabolism
Nitric Oxide / biosynthesis*
Plant Oils / chemistry,  therapeutic use*
Propionibacterium acnes / drug effects*,  growth & development
Staphylococcus epidermidis / drug effects*,  growth & development
Reg. No./Substance:
0/Cytokines; 0/Lipopolysaccharides; 0/Plant Oils; 10102-43-9/Nitric Oxide

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