| Cryptococcus neoformans and Candida albicans regulate CD4 expression on human monocytes. | |
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MedLine Citation:
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PMID: 9780269 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study examined the capability of Candida albicans and Cryptococcus neoformans to modulate CD4 expression on human monocytes. C. albicans and an acapsular strain of C. neoformans induced higher levels of CD4 expression than encapsulated strains. Purified glucuronoxylomannan did not regulate CD4 expression on monocytes, but down-regulation of CD4 expression compared with stimulation by acapsular C. neoformans alone was observed when glucuronoxylomannan was used in combination with acapsular C. neoformans. The ability of opsonic factors to facilitate fungal-mediated CD4 overexpression suggests that binding or internalization (or both) of the yeast cells is a critical event. Protein synthesis was required, excluding redistribution of the intracellular pool of CD4 receptors to the cellular surface as the sole possible mechanism. Results demonstrate a new effect of fungi on professional phagocytic cells and raise the possibility that modulation of CD4 could influence gp120-mediated human immunodeficiency virus entry. |
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Authors:
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D Pietrella; C Monari; C Retini; B Palazzetti; T R Kozel; A Vecchiarelli |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Journal of infectious diseases Volume: 178 ISSN: 0022-1899 ISO Abbreviation: J. Infect. Dis. Publication Date: 1998 Nov |
Date Detail:
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Created Date: 1998-12-10 Completed Date: 1998-12-10 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0413675 Medline TA: J Infect Dis Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1464-71 Citation Subset: AIM; IM; X |
Affiliation:
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Microbiology Section Department of Experimental Medicine, University of Perugia, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antigens, CD4
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biosynthesis* Candida albicans / drug effects, immunology* Cryptococcus neoformans / drug effects, immunology* Cycloheximide / pharmacology Dactinomycin / pharmacology HIV Envelope Protein gp120 / metabolism Humans Monocytes / drug effects, immunology, metabolism*, microbiology Protein Synthesis Inhibitors / pharmacology Surface Properties Up-Regulation |
| Grant Support | |
ID/Acronym/Agency:
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AI-14209/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD4; 0/HIV Envelope Protein gp120; 0/Protein Synthesis Inhibitors; 50-76-0/Dactinomycin; 66-81-9/Cycloheximide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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