Document Detail

Cryptococcosis in ferrets: a diverse spectrum of clinical disease.
MedLine Citation:
PMID:  12537139     Owner:  NLM     Status:  MEDLINE    
Cryptococcosis was diagnosed in seven ferrets (five from Australia; two from western Canada) displaying a wide range of clinical signs. Two of the ferrets lived together. One (5-years-old) had cryptococcal rhinitis and presented when the infection spread to the nasal bridge. Its sibling developed cryptococcal abscessation of the right retropharyngeal lymph node 12 months later, soon after developing a severe skin condition. DNA fingerprinting and microsatellite analysis demonstrated that the two strains isolated from these siblings were indistinguishable. Two ferrets (2- to 3-years-old) developed generalised cryptococcosis: one had primary lower respiratory tract disease with pneumonia, pleurisy and mediastinal lymph node involvement, while in the other a segment of intestine was the primary focus of infection with subsequent spread to mesenteric lymph nodes, liver and lung. The remaining three ferrets (1.75 to 4-years-old) had localised disease of a distal limb, in one case with spread to the regional lymph node. Cryptococcus bacillisporus (formerly C. neoformans var gattii) accounted for three of the four infections in Australian ferrets where the biotype could be determined. The Australian ferret with intestinal involvement and the two ferrets from Vancouver had C. neoformans var grubii infections.
R Malik; B Alderton; D Finlaison; M B Krockenberger; H Karaoglu; W Meyer; P Martin; M P France; J McGill; S J Lester; C R O'Brien; D N Love
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Australian veterinary journal     Volume:  80     ISSN:  0005-0423     ISO Abbreviation:  Aust. Vet. J.     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2003-01-22     Completed Date:  2003-02-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370616     Medline TA:  Aust Vet J     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  749-55     Citation Subset:  IM    
Faculty of Veterinary Science, The University of Sydney, New South Wales, 2006.
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MeSH Terms
British Columbia
Cryptococcosis / diagnosis,  pathology,  radiography,  veterinary*
Cryptococcus neoformans / genetics*,  isolation & purification
DNA Fingerprinting / veterinary
DNA Primers
Diagnosis, Differential
Microsatellite Repeats
New South Wales
Polymerase Chain Reaction / veterinary
Respiratory Tract Infections / diagnosis,  veterinary*
Rhinitis / diagnosis,  veterinary*
Reg. No./Substance:
0/DNA Primers

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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