Document Detail


Crypt abscesses in the caeca of feral rabbits in a rabbit haemorrhagic disease endemic region of New Zealand.
MedLine Citation:
PMID:  17928901     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: To describe the pathology of crypt abscesses in the caeca of feral rabbits in the Manawatu region of New Zealand, and to examine the possible relationship between their prevalence and rabbit haemorrhagic disease (RHD) virus (RHDV) infection. METHODS: During the course of a 3-year study of RHD, 173 wild rabbits (Oryctolagus cuniculus) were shot on three pastoral livestock farms in the Manawatu region of New Zealand. All rabbits were necropsied, and tissue samples of the caeca were examined histologically. The age of each animal was determined, and blood samples collected for the detection of RHDV antibodies. Logistic regression was used to model the odds of rabbits having crypt abscesses. RESULTS: At necropsy, 63/173 (36.4%) rabbits were found to have small circular black nodules on the mucosal surface of their appendix caecum and/or sacculus rotundus. Microscopically, these were identified as small crypt abscesses composed of dilated sacs at the base of the mucosa that were often lined by a thin layer of attenuated epithelial cells. They usually contained large amounts of concentrically-laminated mucopolysaccharide material that was sometimes pigmented, inflammatory debris, and were often the site of a moderate multifocal appendicitis. Although RHDV was active in the study area, no association was found between RHDV antibodies in serum and the presence of lesions. The lesions were more common in older individuals and those born in summer or autumn. CONCLUSIONS: This is the first report of crypt abscesses with inflammation and necrotic debris in the caeca of rabbits. No association between the occurrence of crypt abscesses and RHDV infection was identified. Wild rabbits born in a particular season were presumably exposed very early in life to conditions that caused the crypt abscesses to develop. Alternatively, association with season of birth may represent rabbits that were of similar age in a later stage of their lives, when they became exposed to the cause of the lesions, which remains unidentified.
Authors:
J Henning; M R Alley
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  New Zealand veterinary journal     Volume:  55     ISSN:  0048-0169     ISO Abbreviation:  N Z Vet J     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-10-11     Completed Date:  2007-11-26     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0021406     Medline TA:  N Z Vet J     Country:  New Zealand    
Other Details:
Languages:  eng     Pagination:  239-43     Citation Subset:  IM    
Affiliation:
Institute of Veterinary, Animal and Biomedical Sciences, Massey University, Palmerston North, New zealand. j.henning@uq.edu.au
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MeSH Terms
Descriptor/Qualifier:
Abscess / epidemiology,  veterinary
Animals
Animals, Wild
Caliciviridae Infections / epidemiology,  veterinary*
Cecum / pathology*
Female
Hemorrhagic Disease Virus, Rabbit / isolation & purification*
Male
New Zealand / epidemiology
Rabbits

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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