Document Detail

Cryotherapy of the uterine cervix: an inadequate treatment modality in a newly screened population.
MedLine Citation:
PMID:  7404026     Owner:  NLM     Status:  MEDLINE    
A prospective trial of the efficacy of cryotherapy in cervical intra-epithelial neoplasia (CIN) was initiated at Baragwanath Hospital in Soweto, and incorporated 200 Black patients who had been evaluated by colposcopy and directed cervical biopsy before inclusion in the study. Only 52 patients (26%) achieved cytonegativity and adhered to the continuing follow-up schedule as advised (12 of these patients required repeat cryotherapy to achieve a cure). Another 39 patients (19,5%) were cytonegative when last seen, but did not fulfil the follow-up criteria required. Inclusive of this latter group, the cure rate achieved was 45,5% of the entire series, the average follow-up period being only 7,08 months. The results of the study demonstrated that cryotherapy cannot be regarded as the ideal form of management of CIN in a newly screened population, in whom the lesions detected are often extensive, with deep intraglandular involvement, and extension into the endocervical canal. For maximal therapeutic efficacy in any new cancer screening programme, it is advised that a policy of more liberal recourse to cold-knife conization be adopted, cryotherapy being reserved for patients with lesser degrees of CIN, in whom the lesion is confined to the surface epithelium of the ectocervix only
G Leiman; A D Andronikou
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde     Volume:  57     ISSN:  0256-9574     ISO Abbreviation:  S. Afr. Med. J.     Publication Date:  1980 Jan 
Date Detail:
Created Date:  1980-10-27     Completed Date:  1980-10-27     Revised Date:  2014-09-12    
Medline Journal Info:
Nlm Unique ID:  0404520     Medline TA:  S Afr Med J     Country:  SOUTH AFRICA    
Other Details:
Languages:  eng     Pagination:  39-43     Citation Subset:  IM    
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MeSH Terms
Carcinoma in Situ / surgery*
Follow-Up Studies
Middle Aged
Uterine Cervical Neoplasms / surgery*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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